Vitamin K intake and atherosclerosis

@article{Erkkil2008VitaminKI,
  title={Vitamin K intake and atherosclerosis},
  author={Arja T. Erkkil{\"a} and Sarah L Booth},
  journal={Current Opinion in Lipidology},
  year={2008},
  volume={19},
  pages={39–42}
}
Purpose of review It has been hypothesized that insufficient intake of vitamin K may increase soft-tissue calcification owing to impaired γ-carboxylation of the vitamin K-dependent protein matrix γ-carboxyglutamic acid. The evidence to support this putative role of vitamin K intake in atherosclerosis is reviewed. Recent findings In animal models, multiple forms of vitamin K have been shown to reverse the arterial calcification created by vitamin K antagonists. The human data, however, are less… 
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  • Biology
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  • 2009
TLDR
This work has shown that the biochemical function of vitamin K may extend beyond that of a cofactor for the VKD carboxylation of glutamyl residues (Glus) toCarboxylated Glus in VKD proteins.
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TLDR
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TLDR
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TLDR
The very limited results of this review highlight the lack of evidence currently available to determine the effectiveness of vitamin K supplementation for the primary prevention of cardiovascular disease, and demonstrate the need for further high quality trials in this area.
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TLDR
Current observational and indirect interventional evidence appears to support a relationship between ucOC with metabolic and cardiovascular disease and emerging evidence to suggest a direct role of uc OC in human metabolism.
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TLDR
Investigation of effects of vitamin K-1 and menaquinone-7 treatments on blood pressure and vascular function in warfarin-induced vascular calcification model during five-week intervention in normotensive Wistar-Kyoto rats found that the relaxation in those groups was not totally dependent on NO.
Vitamin K, an example of triage theory: is micronutrient inadequacy linked to diseases of aging?
  • J. McCann, B. Ames
  • Biology, Medicine
    The American journal of clinical nutrition
  • 2009
TLDR
A triage perspective reinforces recommendations of some experts that much of the population and warfarin/coumadin patients may not receive sufficient vitamin K for optimal function of VKD proteins that are important to maintain long-term health.
The Discovery of Vitamin K and Its Clinical Applications
  • G. Ferland
  • Biology
    Annals of Nutrition and Metabolism
  • 2012
TLDR
Major progress in the understanding of the mechanisms of action of vitamin K came in the 1970s with the discovery of γ-carboxyglutamic acid (Gla), a new amino acid common to all vitamin K proteins.
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TLDR
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TLDR
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