Vitamin K-dependent carboxylase activity, prothrombin mRNA, and prothrombin production in two cultured rat hepatoma cell lines.

@article{Shah1993VitaminKC,
  title={Vitamin K-dependent carboxylase activity, prothrombin mRNA, and prothrombin production in two cultured rat hepatoma cell lines.},
  author={Dhavtm V. Shah and P Zhang and Jean A Engelke and Ariadne Bach and John W Suttie},
  journal={Thrombosis research},
  year={1993},
  volume={70 5},
  pages={365-73}
}
The presence of under-gamma-carboxylated forms of plasma prothrombin is a marker for human primary hepatocellular carcinoma. A rat hepatoma cell line (7777) which was previously shown to secrete undercarboxylated prothrombin when grown as a solid tumor has now been grown in monolayer culture. This cell line has a decreased activity of the microsomal vitamin… CONTINUE READING