Vitamin K Analogs Influence the Growth and Virulence Potential of Enterohemorrhagic Escherichia coli

  title={Vitamin K Analogs Influence the Growth and Virulence Potential of Enterohemorrhagic Escherichia coli},
  author={Anne Kijewski and Ingun Lund Wits{\o} and Hildegunn Iversen and Helene Thorsen R{\o}nning and Trine M. L’Ab{\'e}e-Lund and Yngvild Wasteson and Toril Lindbäck and Marina Aspholm},
  journal={Applied and Environmental Microbiology},
Enterohemorrhagic E. coli (EHEC) can cause serious illness and deaths in humans by producing toxins that can severely damage our intestines and kidneys. There is currently no optimal treatment for EHEC infections, as antibiotics can worsen disease development. Consequently, the need for new treatment options is urgent. Environmental factors in our intestines can affect the virulence of EHEC and help our bodies fight EHEC infections. The ruminant intestine, the main reservoir for EHEC, contains… 
2 Citations
Potential of Bacterial Strains Isolated from Coastal Water for Wastewater Treatment and as Aqua-Feed Additives
The results indicated that the 4 bacterial strains can be effectively utilized for biological wastewater treatment processes and as aqua-feed.
Epigallocatechin Gallate Can Protect Mice From Acute Stress Induced by LPS While Stabilizing Gut Microbes and Serum Metabolites Levels
It is believed that EGCG can protect mice from acute stress induced by LPS while stabilizing gut microbes in general, improving the metabolism of sphingolipids, and inhibiting the content of harmful metabolites.


Retinoid Levels Influence Enterohemorrhagic Escherichia coli Infection and Shiga Toxin 2 Susceptibility in Mice
It is reported that VA deficiency worsened the intestinal damage during EHEC infection but simultaneously improved survival, supporting the idea that they have a proinflammatory effect by acting, in part, on the PMN population.
Roles of Shiga Toxins in Immunopathology
Studies describing Stx-induced innate immune responses that may be associated with tissue damage, inflammation, and complement activation are reviewed and it is speculated on how these processes may contribute to immunopathological responses to the toxins.
Nitric oxide inhibits Shiga-toxin synthesis by enterohemorrhagic Escherichia coli
It is demonstrated that chemical or cellular sources of NO inhibit spontaneous and mitomycin C-induced stx mRNA expression and Stx synthesis, without altering EHEC viability, and that the synthesis of stx phage is reduced by NO.
Human Neutrophils and Their Products Induce Shiga Toxin Production by Enterohemorrhagic Escherichia coli
Both H2O2 and neutrophils were found to augment Stx2 production, raising the possibility that these agents may lead to prophage induction in vivo and thereby contribute to EHEC pathogenesis.
Enterohemorrhagic Escherichia coli senses low biotin status in the large intestine for colonization and infection
A virulence-regulating pathway in which the biotin protein ligase BirA signals to the global regulator Fur, which activates LEE genes to promote EHEC adherence in the low-biotin large intestine, thus preventing adherence and ensuring selective colonization of the large intestine is identified.
Phenethyl Isothiocyanate Inhibits Shiga Toxin Production in Enterohemorrhagic Escherichia coli by Stringent Response Induction
ABSTRACT The pathogenicity of enterohemorrhagic Escherichia coli (EHEC) depends on production of Shiga toxins, which are encoded by stx genes located in the genomes of lambdoid prophages. Efficient
Vitamin B12 Uptake by the Gut Commensal Bacteria Bacteroides thetaiotaomicron Limits the Production of Shiga Toxin by Enterohemorrhagic Escherichia coli
Vitamin B12 is highlighted as a molecule produced by gut microbiota that modulates production of a key virulence factor of EHEC and consequently may affect the outcome of an infection.
Commensal E. coli Stx2 lysogens produce high levels of phages after spontaneous prophage induction
Based on the findings, a high Stx2 production by commensal E. coli lysogens cannot be ruled out as a contributor to the high frequency of HUS during this outbreak.
The gut commensal Bacteroides thetaiotaomicron exacerbates enteric infection through modification of the metabolic landscape.
It is shown that Bt enhances EHEC virulence gene expression through the transcription factor Cra, which is functionally sensitive to sugar concentrations, and suggest that microbiota composition affects disease outcome and may explain links between microbiota composition and disease susceptibility.
Manganese Blocks Intracellular Trafficking of Shiga Toxin and Protects Against Shiga Toxicosis
It is found that the widely available metal manganese (Mn2+) blocked endosome-to-Golgi trafficking of STx and caused its degradation in lysosomes, which conferred very high levels of protection of cultured cells against toxin-induced death and made mice completely resistant to Shiga toxin–induced paralysis and death.