Vitamin K Analogs Influence the Growth and Virulence Potential of Enterohemorrhagic Escherichia coli

@article{Kijewski2020VitaminKA,
  title={Vitamin K Analogs Influence the Growth and Virulence Potential of Enterohemorrhagic Escherichia coli},
  author={Anne Kijewski and Ingun Lund Wits{\o} and Hildegunn Iversen and Helene Thorsen R{\o}nning and Trine M. L’Ab{\'e}e-Lund and Yngvild Wasteson and Toril Lindbäck and Marina Aspholm},
  journal={Applied and Environmental Microbiology},
  year={2020},
  volume={86}
}
Enterohemorrhagic E. coli (EHEC) can cause serious illness and deaths in humans by producing toxins that can severely damage our intestines and kidneys. There is currently no optimal treatment for EHEC infections, as antibiotics can worsen disease development. Consequently, the need for new treatment options is urgent. Environmental factors in our intestines can affect the virulence of EHEC and help our bodies fight EHEC infections. The ruminant intestine, the main reservoir for EHEC, contains… Expand
1 Citations
Epigallocatechin Gallate Can Protect Mice From Acute Stress Induced by LPS While Stabilizing Gut Microbes and Serum Metabolites Levels
TLDR
It is believed that EGCG can protect mice from acute stress induced by LPS while stabilizing gut microbes in general, improving the metabolism of sphingolipids, and inhibiting the content of harmful metabolites. Expand

References

SHOWING 1-10 OF 95 REFERENCES
Retinoid Levels Influence Enterohemorrhagic Escherichia coli Infection and Shiga Toxin 2 Susceptibility in Mice
TLDR
It is reported that VA deficiency worsened the intestinal damage during EHEC infection but simultaneously improved survival, supporting the idea that they have a proinflammatory effect by acting, in part, on the PMN population. Expand
Roles of Shiga Toxins in Immunopathology
TLDR
Studies describing Stx-induced innate immune responses that may be associated with tissue damage, inflammation, and complement activation are reviewed and it is speculated on how these processes may contribute to immunopathological responses to the toxins. Expand
Nitric oxide inhibits Shiga-toxin synthesis by enterohemorrhagic Escherichia coli
TLDR
It is demonstrated that chemical or cellular sources of NO inhibit spontaneous and mitomycin C-induced stx mRNA expression and Stx synthesis, without altering EHEC viability, and that the synthesis of stx phage is reduced by NO. Expand
Human Neutrophils and Their Products Induce Shiga Toxin Production by Enterohemorrhagic Escherichia coli
TLDR
Both H2O2 and neutrophils were found to augment Stx2 production, raising the possibility that these agents may lead to prophage induction in vivo and thereby contribute to EHEC pathogenesis. Expand
Enterohemorrhagic Escherichia coli senses low biotin status in the large intestine for colonization and infection
TLDR
A virulence-regulating pathway in which the biotin protein ligase BirA signals to the global regulator Fur, which activates LEE genes to promote EHEC adherence in the low-biotin large intestine, thus preventing adherence and ensuring selective colonization of the large intestine is identified. Expand
Phenethyl Isothiocyanate Inhibits Shiga Toxin Production in Enterohemorrhagic Escherichia coli by Stringent Response Induction
ABSTRACT The pathogenicity of enterohemorrhagic Escherichia coli (EHEC) depends on production of Shiga toxins, which are encoded by stx genes located in the genomes of lambdoid prophages. EfficientExpand
Vitamin B12 Uptake by the Gut Commensal Bacteria Bacteroides thetaiotaomicron Limits the Production of Shiga Toxin by Enterohemorrhagic Escherichia coli
TLDR
Vitamin B12 is highlighted as a molecule produced by gut microbiota that modulates production of a key virulence factor of EHEC and consequently may affect the outcome of an infection. Expand
Commensal E. coli Stx2 lysogens produce high levels of phages after spontaneous prophage induction
TLDR
Based on the findings, a high Stx2 production by commensal E. coli lysogens cannot be ruled out as a contributor to the high frequency of HUS during this outbreak. Expand
The gut commensal Bacteroides thetaiotaomicron exacerbates enteric infection through modification of the metabolic landscape.
TLDR
It is shown that Bt enhances EHEC virulence gene expression through the transcription factor Cra, which is functionally sensitive to sugar concentrations, and suggest that microbiota composition affects disease outcome and may explain links between microbiota composition and disease susceptibility. Expand
Manganese Blocks Intracellular Trafficking of Shiga Toxin and Protects Against Shiga Toxicosis
TLDR
It is found that the widely available metal manganese (Mn2+) blocked endosome-to-Golgi trafficking of STx and caused its degradation in lysosomes, which conferred very high levels of protection of cultured cells against toxin-induced death and made mice completely resistant to Shiga toxin–induced paralysis and death. Expand
...
1
2
3
4
5
...