Vitamin K, an example of triage theory: is micronutrient inadequacy linked to diseases of aging?

  title={Vitamin K, an example of triage theory: is micronutrient inadequacy linked to diseases of aging?},
  author={Joyce C. McCann and Bruce N. Ames},
  journal={The American journal of clinical nutrition},
  volume={90 4},
  • J. McCannB. Ames
  • Published 1 October 2009
  • Biology, Medicine
  • The American journal of clinical nutrition
The triage theory posits that some functions of micronutrients (the approximately 40 essential vitamins, minerals, fatty acids, and amino acids) are restricted during shortage and that functions required for short-term survival take precedence over those that are less essential. Insidious changes accumulate as a consequence of restriction, which increases the risk of diseases of aging. For 16 known vitamin K-dependent (VKD) proteins, we evaluated the relative lethality of 11 known mouse… 

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