Vitamin K, an example of triage theory: is micronutrient inadequacy linked to diseases of aging?

@article{McCann2009VitaminKA,
  title={Vitamin K, an example of triage theory: is micronutrient inadequacy linked to diseases of aging?},
  author={Joyce C. McCann and Bruce N. Ames},
  journal={The American journal of clinical nutrition},
  year={2009},
  volume={90 4},
  pages={
          889-907
        }
}
  • J. McCann, B. Ames
  • Published 1 October 2009
  • Biology, Medicine
  • The American journal of clinical nutrition
The triage theory posits that some functions of micronutrients (the approximately 40 essential vitamins, minerals, fatty acids, and amino acids) are restricted during shortage and that functions required for short-term survival take precedence over those that are less essential. Insidious changes accumulate as a consequence of restriction, which increases the risk of diseases of aging. For 16 known vitamin K-dependent (VKD) proteins, we evaluated the relative lethality of 11 known mouse… 
Vitamin K: the effect on health beyond coagulation – an overview
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TLDR
It is concluded that further investigations are needed to establish how differences among the vitamin K forms may influence tissue specificities and their role in human health, and there is merit for considering both menaquinones and phylloquinone when developing future recommendations for vitamin K intake.
The role of vitamin K in soft-tissue calcification.
TLDR
This study showed maintenance of vascular elasticity during a 3-y supplementation period, with a parallel 12% loss of elasticity in the placebo group, and new conformation-specific assays for circulating uncarboxylated MGP were developed; an assay for desphospho-uncarboxylation matrix Gla protein and another assay for total uncar boxylated matrix GlA protein.
Vitamin K, osteoporosis and degenerative diseases of ageing
TLDR
The function of vitamin K is to serve as a co-factor during the post-translational carboxylation of glutamate (Glu) residues into γ-carboxyglutamate (Gla) residues which is an independent, but modifiable risk factor for the development of degenerative diseases of ageing.
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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Nutritional Effects of γ-Glutamyl Carboxylase Gene Polymorphism on the Correlation between the Vitamin K Status and γ-Carboxylation of Osteocalcin in Young Males
TLDR
This is the first report to suggest the effects of the single nucleotide polymorphism R325Q in the GGCX gene on the correlation between the level of serum MK-7 and γ-carboxylation of serum OC.
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