Vitamin E suppresses isoprostane generation in vivo and reduces atherosclerosis in ApoE-deficient mice

@article{Pratic1998VitaminES,
  title={Vitamin E suppresses isoprostane generation in vivo and reduces atherosclerosis in ApoE-deficient mice},
  author={Domenico Pratic{\`o} and Rajendra K. Tangirala and Daniel J. Rader and Joshua Rokach and Garret A. FitzGerald},
  journal={Nature Medicine},
  year={1998},
  volume={4},
  pages={1189-1192}
}
Oxidative modification of low density lipoprotein (LDL) has been implicated in atherogenesis. Evidence consistent with this hypothesis includes the presence of oxidized lipids in atherosclerotic lesions, the newly discovered biological properties conferred on LDL by oxidation and the acceleration of atherogenesis by in vivo delivery of the gene for 15-lipoxygenase, an oxidizing enzyme present in atherosclerotic lesions. However, it is still unknown whether oxidative stress actually coincides… CONTINUE READING
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References

Publications referenced by this paper.
SHOWING 1-10 OF 26 REFERENCES

Effect of probucol on LDL oxidation and atherosclerosis in LDL receptor - deficient mice

  • D. A. Bird
  • J . Lipid Res .
  • 1998

IPF 2 α - I : A novel index of lipid peroxidation in humans

  • D. Praticò
  • Proc . Natl . Acad . Sci . USA
  • 1998

Increased lipid peroxidation in hepatic cirrhosis

  • D. Praticò
  • J . Investig . Med .
  • 1998

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