Vitamin E supplementation suppresses prostaglandin E1(2) synthesis and enhances the immune response of aged mice.

@article{Meydani1986VitaminES,
  title={Vitamin E supplementation suppresses prostaglandin E1(2) synthesis and enhances the immune response of aged mice.},
  author={Simin Nikbin Meydani and Mohsen Meydani and C. P. Verdon and Andrew A. Shapiro and Jeffrey B Blumberg and K. C. Hayes},
  journal={Mechanisms of ageing and development},
  year={1986},
  volume={34 2},
  pages={191-201}
}
The potential for vitamin E to modulate prostaglandin metabolism and alter immune response in aged mice was studied. Semi-purified diets containing 30 ppm or 500 ppm dl-alpha-tocopheryl acetate (VitE) were fed for 6 weeks to young (3 months) and old (24 months) C57BL/6J mice. Delayed hypersensitivity skin test to DNFB and the proliferative response of splenocytes to T- and B-cell mitogens were assessed. Ex-vivo synthesis of Prostaglandin E2 (PGE2) was measured in spleen homogenates and serum… CONTINUE READING

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