Vitamin E succinate inhibits survivin and induces apoptosis in pancreatic cancer cells

  title={Vitamin E succinate inhibits survivin and induces apoptosis in pancreatic cancer cells},
  author={Dorrelyn Patacsil and Sylvester N. Osayi and Anh Thu Tran and Francisco R. Saenz and Lydia Yimer and Ayesha N. Shajahan and Prafulla C. Gokhale and Mukesh Verma and Robert Clarke and Subhash Chand Chauhan and Deepak Kumar Vijaya Kumar},
  journal={Genes & Nutrition},
Pancreatic cancer is the fourth leading cause of cancer-related deaths in the United States. Identifying novel chemotherapeutic and chemopreventive approaches is critical in the prevention and treatment of cancers such as pancreatic cancer. Vitamin E succinate (VES) is a redox-silent analog of the fat-soluble vitamin alpha-tocopherol. In the present study, we explored the antiproliferative action of VES and its effects on inhibitor of apoptosis proteins in pancreatic cancer cells. We show that… CONTINUE READING
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