Vitamin E protects nerve cells from amyloid beta protein toxicity.

  title={Vitamin E protects nerve cells from amyloid beta protein toxicity.},
  author={Christian Behl and John B. Davis and G. M. Cole and Dave Schubert},
  journal={Biochemical and biophysical research communications},
  volume={186 2},
The amyloid beta protein (ABP) is a 40 to 42 amino acid peptide which accumulates in Alzheimer's disease plaques. It has been demonstrated that this peptide and a fragment derived from it are cytotoxic for cultured cortical nerve cells. It is shown here that ABP and an internal fragment encompassing residues 25 to 35 (beta 25-35) are cytotoxic to a clone of PC12 cells at concentrations above 1 x 10(-9)M and to several other cell lines at higher concentrations. Between 10(-9) and 10(-11) M beta… CONTINUE READING
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