Vitamin E oxidation in human atherosclerotic lesions.

  title={Vitamin E oxidation in human atherosclerotic lesions.},
  author={Andrew C Terentis and Shane Ross Thomas and Jeanne A. Burr and Daniel C. Liebler and Roland Stocker},
  journal={Circulation research},
  volume={90 3},
Oxidation of low-density lipoproteins (LDL) is a key process in atherogenesis, and vitamin E (alpha-tocopherol, TOH) has received attention for its potential to attenuate the disease. Despite this, the type and extent of TOH oxidation and its relationship to lipid oxidation in the vessel wall where lesions develop remain unknown. Therefore, we measured oxidized lipids, TOH, and its oxidation products, alpha-tocopherylquinone (TQ), 2,3- and 5,6-epoxy-alpha-tocopherylquinones by gas… CONTINUE READING


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