Vitamin E inhibits low-density lipoprotein-induced adhesion of monocytes to human aortic endothelial cells in vitro.

@article{Martin1997VitaminEI,
  title={Vitamin E inhibits low-density lipoprotein-induced adhesion of monocytes to human aortic endothelial cells in vitro.},
  author={Antonio Olveira Martin and T. Foxall and Jeffrey B Blumberg and Mohsen Meydani},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={1997},
  volume={17 3},
  pages={429-36}
}
Monocyte adhesion to human aortic endothelial cells (ECs) is one of the early events in the development of atherogenesis. ECs were used to investigate the role of vitamin E in human monocyte adhesion to ECs in vitro. ECs incubated with 40 to 193 mg/dL of low-density lipoprotein cholesterol (LDL) for 22 hours exhibited increasing dose-dependent adherence for untreated, isolated human monocytes (P < .05). ECs exposed to the highest dose of LDL (193 mg/dL) but pretreated with 19 mumol/L alpha… CONTINUE READING