Vitamin E in human low-density lipoprotein. When and how this antioxidant becomes a pro-oxidant.

@article{Bowry1992VitaminEI,
  title={Vitamin E in human low-density lipoprotein. When and how this antioxidant becomes a pro-oxidant.},
  author={Vincent W Bowry and Keith U. Ingold and Roland Stocker},
  journal={The Biochemical journal},
  year={1992},
  volume={288 ( Pt 2)},
  pages={341-4}
}
Uptake of oxidatively modified low-density lipoprotein (LDL) by cells in the arterial wall is believed to be an important early event in the development of atherosclerosis. Because vitamin E is the major antioxidant present in human lipoproteins, it has received much attention as a suppressor of LDL lipid oxidation and as an epidemiological marker for ischaemic heart disease. However, a careful examination of lipid peroxidation in LDL induced by a steady flux of aqueous peroxyl radicals has… CONTINUE READING