Vitamin E in Neurodegenerative Disorders: Alzheimer's Disease

@article{Kontush2004VitaminEI,
  title={Vitamin E in Neurodegenerative Disorders: Alzheimer's Disease},
  author={Anatol Kontush and Svetlana Schekatolina},
  journal={Annals of the New York Academy of Sciences},
  year={2004},
  volume={1031}
}
Abstract: Oxidative stress is important in the pathogenesis of Alzheimer's disease (AD). The brain contains high levels of oxidizable lipids that must be protected by antioxidants. Low concentrations of vitamin E, quantitatively the major lipophilic antioxidant in the brain, are frequently observed in cerebrospinal fluid (CSF) of AD patients, suggesting that supplementation with vitamin E might delay the development of AD. In a placebo‐controlled trial, vitamin E (2000 IU/day, 2 years) slowed… Expand
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