Vitamin E deficiency in variant angina.

  title={Vitamin E deficiency in variant angina.},
  author={Kunihisa Miwa and Y Miyagi and Akihiko Igawa and Keiko Nakagawa and Hiroko Inoue},
  volume={94 1},
BACKGROUND Oxidative modification of LDL has been suggested to increase coronary vasoreactivity to agonists. A deficiency of vitamin E, a major antioxidant, may be related to the occurrence of coronary artery spasm. METHODS AND RESULTS Vitamin E levels were determined with the use of high-performance liquid chromatography in normolipidemic subjects, including 29 patients with active variant angina (group 1), 13 patients with inactive stage of variant angina without anginal attacks during the… 

Cholesterol standardized plasma vitamin E levels are reduced in patients with severe angina pectoris.

High plasma vitamin E: total cholesterol ratio may be associated with an amelioration of angina, and has previously been demonstrated to protect endothelial function in the presence of hypercholesterolaemia, possibly by preserving nitric oxide bio-activity.

Vitamin E improves fibrinolytic activity in patients with coronary spastic angina.

Vitamin E administration improves impairment of endothelium-dependent vasodilation in patients with coronary spastic angina.

Enhanced susceptibility to oxidation and diminished vitamin E content of LDL from patients with stable coronary artery disease.

The data suggest that a short LDL oxidation lag time and a low concentration of vitamin E in LDL might be independent coronary risk factors for stable CAD in Iranian people.

Low Serum α-Tocopherol Concentrations in Subjects With Various Coronary Risk Factors

Increased oxidative stress, as shown by decreased α-tocopherol concentrations, was linked to the presence of various coronary risk factors, among which hyperTG and hypoHDL-C appeared to be most heavily associated with oxidative stress.

Increased Autoantibodies Against Oxidized Low-Density Lipoprotein in Coronary Circulation in Patients with Coronary Spastic Angina

Elevated levels of autoantibodies against malondialdehyde-modified oxidized low-density lipoproteins in coronary circulation are associated with the development of atherothrombosis from the progression of atherosclerosis rather than with the extent of coronary atheroscle rosis in patients with coronary spastic angina.



Dietary antioxidants preserve endothelium-dependent vessel relaxation in cholesterol-fed rabbits.

  • J. KeaneyJ. Gaziano J. Vita
  • Biology, Medicine
    Proceedings of the National Academy of Sciences of the United States of America
  • 1993
The results suggest that dietary antioxidants may benefit patients with atherosclerosis by preserving endothelial vasodilator function through a mechanism related to vascular tissue antioxidant content and not reflected by assay of low density lipoprotein resistance to ex vivo oxidation.

Pathogenesis of unstable angina with 0- or 1-vessel disease. Important role of coronary artery spasm.

It is concluded that dynamic coronary obstruction plays an important role in the genesis of attacks in patients with unstable angina who had 0- or 1-vessel organic coronary artery disease.

Mechanisms of copper- and iron-dependent oxidative modification of human low density lipoprotein.

Oxidative modification of low density lipoprotein (LDL) has been suggested as a causal step in atherosclerosis, and both redox-active transition metal ions and superoxide (O2.-) have been implicated

Low density lipoprotein undergoes oxidative modification in vivo.

Three mutually supportive lines of evidence for oxidation of LDL in vivo are presented and autoantibodies against malondialdehyde-LDL (titers from 512 to greater than 4096) can be demonstrated in rabbit and human sera.

Ubiquinol-10 protects human low density lipoprotein more efficiently against lipid peroxidation than does alpha-tocopherol.

  • R. StockerV. BowryB. Frei
  • Chemistry, Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1991
Investigation of the temporal disappearance of natural antioxidants associated with human low density lipoprotein (LDL) in relation to the appearance of various classes of lipid hydroperoxides shows that ubiquinol-10 is much more efficient in inhibiting LDL oxidation than either lycopene, beta-carotene, or alpha-tocopherol.

Oxidized low density lipoproteins potentiate vasoconstrictions to various agonists by direct interaction with vascular smooth muscle.

It is suggested that ox-LDL is an important factor that may increase the risk of inappropriate vasoconstriction in hypercholesterolemia, independent of its putative cytotoxic effect on the endothelium.