Vitamin E deficiency in variant angina.

@article{Miwa1996VitaminED,
  title={Vitamin E deficiency in variant angina.},
  author={Kunihisa Miwa and Yu Miyagi and Akihiko Igawa and Keiko Nakagawa and Hiroko Inoue},
  journal={Circulation},
  year={1996},
  volume={94 1},
  pages={
          14-8
        }
}
BACKGROUND Oxidative modification of LDL has been suggested to increase coronary vasoreactivity to agonists. A deficiency of vitamin E, a major antioxidant, may be related to the occurrence of coronary artery spasm. METHODS AND RESULTS Vitamin E levels were determined with the use of high-performance liquid chromatography in normolipidemic subjects, including 29 patients with active variant angina (group 1), 13 patients with inactive stage of variant angina without anginal attacks during the… 

Cholesterol standardized plasma vitamin E levels are reduced in patients with severe angina pectoris.

High plasma vitamin E: total cholesterol ratio may be associated with an amelioration of angina, and has previously been demonstrated to protect endothelial function in the presence of hypercholesterolaemia, possibly by preserving nitric oxide bio-activity.

Cholesterol standardized plasma vitamin E levels are reduced in patients with severe angina pectoris

Vitamin E has previously been demonstrated to protect endothelial function in the presence of hypercholesterolaemia, possibly by preserving nitric oxide Int.

Vitamin E improves fibrinolytic activity in patients with coronary spastic angina.

Vitamin E administration improves impairment of endothelium-dependent vasodilation in patients with coronary spastic angina.

Enhanced susceptibility to oxidation and diminished vitamin E content of LDL from patients with stable coronary artery disease.

The data suggest that a short LDL oxidation lag time and a low concentration of vitamin E in LDL might be independent coronary risk factors for stable CAD in Iranian people.

Increased Autoantibodies Against Oxidized Low-Density Lipoprotein in Coronary Circulation in Patients with Coronary Spastic Angina

Elevated levels of autoantibodies against malondialdehyde-modified oxidized low-density lipoproteins in coronary circulation are associated with the development of atherothrombosis from the progression of atherosclerosis rather than with the extent of coronary atheroscle rosis in patients with coronary spastic angina.
...

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