Vitamin E and wound healing: an evidence‐based review

  title={Vitamin E and wound healing: an evidence‐based review},
  author={Rachel Hobson},
  journal={International Wound Journal},
  • R. Hobson
  • Published 1 June 2016
  • Biology, Medicine
  • International Wound Journal
Vitamin E has been demonstrated to modulate cellular signalling, gene expression and affect wounds infected with methicillin-resistant Staphylococcus aureus (MRSA), thus influencing wound healing. [] Key Method Literature dated from 1996 to 2012, published in English, involving either animals or adult humans with an acute or chronic wound were included. The databases that contained relevant articles were narrowed down to four, and a total of 33 identified studies were included. The literature review revealed…
[Nutrition in the prevention and healing of chronic wounds. Importance in improving the diabetic foot].
In patients with diabetic foot, supplementation with vitamins D, C, A, and E, magnesium, zinc, omega-3 fatty acids, and probiotics reduces ulcer size and improves glycemic control, although they have not been associated with complete healing.
Aloe vera: A medicinal plant used in skin wound healing.
The process of skin injury and wound healing is described, the role of Aloe vera is analyzed, and the types of wound dressing and the applications of AlOE vera in wound dressing will be discussed.
Nutritional therapy and wound healing in pressure injury situations: an integrative review
Some nutrients have been used extensively in the treatment of pressure injuries and are often positively associated with the healing process, highlighting the hyperproteic nutritional therapy enriched with arginine, zinc, and vitamin C, although there is no consensus on the topic.
&agr;‐Tocopherol promotes HaCaT keratinocyte wound repair through the regulation of polarity proteins leading to the polarized cell migration
Results suggest that α-Toc promotes HaCaT keratinocyte wound repair by regulating the aP KC kinase activity and the formation of aPKC-Par3 complex during wound healing.
Preparation and Comparison of Effects of Different Herbal Oil Ointments as Wound-Healing Agents
Lemon and sesame oil ointments could be considered as alternative dressings for infected full-thickness wounds because of improved wound healing characteristics.
The Physiological Mechanisms of Effect of Vitamins and Amino Acids on Tendon and Muscle Healing: A Systematic Review.
Preliminary evidence exists, demonstrating that vitamins and amino acids may facilitate multilevel changes in musculotendinous healing; however, recommendations on clinical utility should be made with caution.
Controlled Release of the α-Tocopherol-Derived Metabolite α-13′-Carboxychromanol from Bacterial Nanocellulose Wound Cover Improves Wound Healing
The potential of α-13′-COOH combined with BNC as a potential active wound dressing for the advanced therapy of skin injuries is highlighted, mainly when a diabetic condition was induced before the injury.
Alpha tocopherol loaded chitosan oleate nanoemulsions for wound healing. Evaluation on cell lines and ex vivo human biopsies, and stabilization in spray dried Trojan microparticles
  • M. C. Bonferoni, F. Riva, F. Ferrari
  • Biology
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
  • 2018


Raxofelast, a hydrophilic vitamin E-like antioxidant, stimulates wound healing in genetically diabetic mice.
Evidence is provided that raxofelast restores wound healing to nearly normal levels in experimental diabetes-impaired wounds and suggests that an increased lipid peroxidation in diabetic mice may have a role in determining a defect of wound repair.
Comparative effects of palm vitamin E and α-tocopherol on healing and wound tissue antioxidant enzyme levels in diabetic rats
Results showed that PVE had a greater potency to enhance wound repair and induce the increase in free radical-scavenging enzyme activities than α-Toc, which were potent antioxidants and significantly reduced the lipid peroxidation levels in the wounds as measured by the reduction in MDA levels.
Antioxidant status in delayed healing type of wounds
  • A. Rasik, A. Shukla
  • Biology, Medicine
    International journal of experimental pathology
  • 2000
Surprisingly, the analysis of 7‐d wound tissue showed higher levels of SOD, catalase, GPx, and GSH and lower TBARS level in athymic mice compared to the wound tissue of normal mice.
Effect of vitamin E on plasma malondialdehyde, antioxidant enzyme levels and the rates of wound closures during wound healing in normal and diabetic rats.
Results showed that alpha-tocopherol reduced plasma malondialdehyde levels, increased glutathione peroxidase activity and accelerated the rate of wound closure in treated rats.
Short term supplementation of dietary antioxidants selectively regulates the inflammatory responses during early cutaneous wound healing in diabetic mice
It is demonstrated that delayed wound healing is associated with an inflammatory response induced by hyperglycaemia, and suggests that dietary antioxidant supplementation may have beneficial effects on wound healing through selective modulation of blood glucose levels, oxidative stress, and inflammatory response.
Vitamin E improves the in vivo efficacy of tigecycline and daptomycin in an animal model of wounds infected with meticillin-resistant Staphylococcus aureus.
The increased antimicrobial effect seen from treatment with VE plus antibiotics was associated with increased levels of natural killer cell cytotoxicity, with a more pronounced increase in leukocyte populations in mice treated with Ve plus DAP, suggesting that treatment withVE prior to infection and subsequent antibiotic treatment act in synergy.
Depletion of reduced glutathione, ascorbic acid, vitamin E and antioxidant defence enzymes in a healing cutaneous wound.
The results indicate that wounding results in loss of different free radical scavengers both enzymatic and non-enzymatic which either partially or completely recover following healing.
Cytokine response to vitamin E supplementation is dependent on pre‐supplementation cytokine levels
The results offer evidence that baseline cytokine production should be considered in studies that examine the effect of supplemental vitamin E on immune and inflammatory responses, and could have implications in designing clinical trials to determine the impact ofitamin E on conditions in which cytokines are implicated such as infections and atherosclerotic disease.