Vitamin E and wound healing: an evidence‐based review

@article{Hobson2016VitaminEA,
  title={Vitamin E and wound healing: an evidence‐based review},
  author={Rachel Hobson},
  journal={International Wound Journal},
  year={2016},
  volume={13}
}
  • R. Hobson
  • Published 1 June 2016
  • Biology, Medicine
  • International Wound Journal
Vitamin E has been demonstrated to modulate cellular signalling, gene expression and affect wounds infected with methicillin-resistant Staphylococcus aureus (MRSA), thus influencing wound healing. [] Key Method Literature dated from 1996 to 2012, published in English, involving either animals or adult humans with an acute or chronic wound were included. The databases that contained relevant articles were narrowed down to four, and a total of 33 identified studies were included. The literature review revealed…
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Results suggest that α-Toc promotes HaCaT keratinocyte wound repair by regulating the aP KC kinase activity and the formation of aPKC-Par3 complex during wound healing.
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Lemon and sesame oil ointments could be considered as alternative dressings for infected full-thickness wounds because of improved wound healing characteristics.
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  • M. C. Bonferoni, F. Riva, F. Ferrari
  • Biology
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References

SHOWING 1-10 OF 56 REFERENCES
Raxofelast, a hydrophilic vitamin E-like antioxidant, stimulates wound healing in genetically diabetic mice.
TLDR
Evidence is provided that raxofelast restores wound healing to nearly normal levels in experimental diabetes-impaired wounds and suggests that an increased lipid peroxidation in diabetic mice may have a role in determining a defect of wound repair.
Comparative effects of palm vitamin E and α-tocopherol on healing and wound tissue antioxidant enzyme levels in diabetic rats
TLDR
Results showed that PVE had a greater potency to enhance wound repair and induce the increase in free radical-scavenging enzyme activities than α-Toc, which were potent antioxidants and significantly reduced the lipid peroxidation levels in the wounds as measured by the reduction in MDA levels.
Antioxidant status in delayed healing type of wounds
  • A. Rasik, A. Shukla
  • Biology, Medicine
    International journal of experimental pathology
  • 2000
TLDR
Surprisingly, the analysis of 7‐d wound tissue showed higher levels of SOD, catalase, GPx, and GSH and lower TBARS level in athymic mice compared to the wound tissue of normal mice.
Effect of vitamin E on plasma malondialdehyde, antioxidant enzyme levels and the rates of wound closures during wound healing in normal and diabetic rats.
TLDR
Results showed that alpha-tocopherol reduced plasma malondialdehyde levels, increased glutathione peroxidase activity and accelerated the rate of wound closure in treated rats.
Short term supplementation of dietary antioxidants selectively regulates the inflammatory responses during early cutaneous wound healing in diabetic mice
TLDR
It is demonstrated that delayed wound healing is associated with an inflammatory response induced by hyperglycaemia, and suggests that dietary antioxidant supplementation may have beneficial effects on wound healing through selective modulation of blood glucose levels, oxidative stress, and inflammatory response.
Vitamin E improves the in vivo efficacy of tigecycline and daptomycin in an animal model of wounds infected with meticillin-resistant Staphylococcus aureus.
TLDR
The increased antimicrobial effect seen from treatment with VE plus antibiotics was associated with increased levels of natural killer cell cytotoxicity, with a more pronounced increase in leukocyte populations in mice treated with Ve plus DAP, suggesting that treatment withVE prior to infection and subsequent antibiotic treatment act in synergy.
Depletion of reduced glutathione, ascorbic acid, vitamin E and antioxidant defence enzymes in a healing cutaneous wound.
TLDR
The results indicate that wounding results in loss of different free radical scavengers both enzymatic and non-enzymatic which either partially or completely recover following healing.
Cytokine response to vitamin E supplementation is dependent on pre‐supplementation cytokine levels
TLDR
The results offer evidence that baseline cytokine production should be considered in studies that examine the effect of supplemental vitamin E on immune and inflammatory responses, and could have implications in designing clinical trials to determine the impact ofitamin E on conditions in which cytokines are implicated such as infections and atherosclerotic disease.
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