Vitamin E and donepezil for the treatment of mild cognitive impairment.

@article{Petersen2005VitaminEA,
  title={Vitamin E and donepezil for the treatment of mild cognitive impairment.},
  author={R. Petersen and R. Thomas and M. Grundman and D. Bennett and R. Doody and S. Ferris and D. Galasko and S. Jin and J. Kaye and A. Levey and E. Pfeiffer and M. Sano and C. V. van Dyck and L. Thal},
  journal={The New England journal of medicine},
  year={2005},
  volume={352 23},
  pages={
          2379-88
        }
}
BACKGROUND Mild cognitive impairment is a transitional state between the cognitive changes of normal aging and early Alzheimer's disease. METHODS In a double-blind study, we evaluated subjects with the amnestic subtype of mild cognitive impairment. Subjects were randomly assigned to receive 2000 IU of vitamin E daily, 10 mg of donepezil daily, or placebo for three years. The primary outcome was clinically possible or probable Alzheimer's disease; secondary outcomes were cognition and function… Expand
1,576 Citations

Paper Mentions

Interventional Clinical Trial
Alzheimer's disease (AD), the most common dementing disorder of later life, is a major cause of disability and death in the elderly. Although a number of theoretical causes exist, the… Expand
ConditionsAlzheimer's Disease, Major Depressive Disorder, Mild Cognitive Impairment
InterventionDrug
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