Vitamin E and adiponectin: proposed mechanism for vitamin E-induced improvement in insulin sensitivity.

@article{Gray2011VitaminEA,
  title={Vitamin E and adiponectin: proposed mechanism for vitamin E-induced improvement in insulin sensitivity.},
  author={Brianna Gray and Jennifer C. Swick and Alayne G. Ronnenberg},
  journal={Nutrition reviews},
  year={2011},
  volume={69 3},
  pages={155-61}
}
Insulin resistance and type 2 diabetes have been treated with the PPARγ agonists thiazolidinediones, or TZDs, since the 1990s. One mechanism by which these drugs may work is through PPARγ-mediated upregulation of adiponectin, an endogenous adipokine that has been shown to increase insulin sensitivity. Interestingly, α- and γ-tocopherol, two vitamin E vitamers, have structural similarities to the TZDs and have also been linked to enhanced insulin sensitivity. A recent study identified a novel… CONTINUE READING

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