Vitamin E-TPGS Increases Absorption Flux of an HIV Protease Inhibitor by Enhancing Its Solubility and Permeability1

@article{Yu1999VitaminEI,
  title={Vitamin E-TPGS Increases Absorption Flux of an HIV Protease Inhibitor by Enhancing Its Solubility and Permeability1},
  author={Lawrence Yu and Avis Bridgers and Joseph W. Polli and Ann W. Vickers and Stacey Long and Arup Roy and Richard Winnike and Mark D. Coffin},
  journal={Pharmaceutical Research},
  year={1999},
  volume={16},
  pages={1812-1817}
}
Purpose. To investigate the effect of vitamin E-TPGS, d-α-tocopheryl polyethylene glycol 1000 succinate, on the solubility and permeability of amprenavir, a potent HIV protease inhibitor. Methods. The aqueous solubility of amprenavir was measured as a function of vitamin E-TPGS concentration. Directional transport through Caco-2 cell monolayers was determined in the presence and absence of vitamin E-TPGS and P-glycoprotein inhibitors. Absorption flux was estimated from Caco-2 cell permeability… CONTINUE READING
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