Vitamin E–drug interactions: molecular basis and clinical relevance

@article{Podszun2014VitaminEI,
  title={Vitamin E–drug interactions: molecular basis and clinical relevance},
  author={Maren C. Podszun and Jan Frank},
  journal={Nutrition Research Reviews},
  year={2014},
  volume={27},
  pages={215 - 231}
}
Vitamin E (α-, β-, γ- and δ-tocopherol and -tocotrienol) is an essential factor in the human diet and regularly taken as a dietary supplement by many people, who act under the assumption that it may be good for their health and can do no harm. With the publication of meta-analyses reporting increased mortality in persons taking vitamin E supplements, the safety of the micronutrient was questioned and interactions with prescription drugs were suggested as one potentially underlying mechanism… 
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TLDR
Findings do not support the hypothesis that α-TOH supplementation interferes with hepatic CYP3A4-mediated drug metabolism, and high-dose vitamin E may be associated with increased mortality in some populations.
Adverse effects of vitamin E by induction of drug metabolism
TLDR
Vitamin E did not provide benefits to patients with cardiovascular diseases, cancer, diabetes or hypertension, and it is recommended to work out at which threshold the drug-metabolizing system can be induced in humans before new trials with high dosages of vitamin E are started.
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TLDR
An overview of the earlier literature on vitamin E is provided, including a critical assessment of three meta-analyses that were neutral or negative toward vitamin E supplementation, and some guidance is offered for healthcare professionals to give to the general, healthy public and those with chronic conditions who are no doubt left puzzled about what to do regarding vitamin E supplements.
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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