Vitamin E: function and metabolism

@article{BrigeliusFlohe1999VitaminEF,
  title={Vitamin E: function and metabolism},
  author={Regina Brigelius-Flohé and Maret G. Traber},
  journal={The FASEB Journal},
  year={1999},
  volume={13},
  pages={1145 - 1155}
}
Although vitamin E has been known as an essential nutrient for reproduction since 1922, we are far from understanding the mechanisms of its physiological functions. Vitamin E is the term for a group of tocopherols and tocotrienols, of which α‐tocopherol has the highest biological activity. Due to the potent antioxidant properties of tocopherols, the impact of α‐tocopherol in the prevention of chronic diseases believed to be associated with oxidative stress has often been studied, and beneficial… Expand
View on Wiley
tocofemax.com.br
1,412 Citations
Highly Influential Citations
43
Background Citations
477
Methods Citations
10
Results Citations
8

1,412 Citations

Citation Type

Citation Type

Vitamin E: non-antioxidant roles.
Vitamin E was originally considered a dietary factor of animal nutrition especially important for normal reproduction. The significance of vitamin E has been subsequently proven as a radical chain… Expand
Regulatory metabolites of vitamin E and their putative relevance for atherogenesis
TLDR
The controversial role of vitamin E as a preventive agent against atherosclerosis is summarized and a role of these long-chain metabolites of α-tocopherol, which are formed as catabolic intermediate products in the liver and occur in human plasma are speculated. Expand
Molecular Aspects of α-Tocotrienol Antioxidant Action and Cell Signalling
Vitamin E, the most important lipid-soluble antioxidant, was discovered at the University of California at Berkeley in 1922 in the laboratory of Herbert M. Evans (Science 1922, 55: 650). At least… Expand
Vitamin E, antioxidant and nothing more.
TLDR
The claim is made that alpha-tocopherol's major vitamin function, if not only function, is that of a peroxyl radical scavenger, which is to maintain the integrity of long-chain polyunsaturated fatty acids in the membranes of cells and thus maintain their bioactivity. Expand
Bioactivity of vitamin E
More than 80 years after the discovery of the essentiality of vitamin E for mammals, the molecular basis of its action is still an enigma. From the eight different forms of vitamin E, only… Expand
Vitamin E: α-Tocopherol and the Other Forms of Vitamin E
Vitamin E has been a generic term for all tocopherol and tocotrienol derivatives. The most active form of vitamin E isoforms in vivo is regarded to be -tocopherol which is the only form defined as… Expand
Alpha-tocopherol: looking beyond an antioxidant
  • K. Engin
  • Biology, Medicine
  • Molecular vision
  • 2009
TLDR
It has been shown in different models that retinal vasculer dysfunction due to hyperglycemia could be prevented by alpha-tocopherol via the diachylglycerol-protein kinase C pathway, and its antiproliferative effect has been demonstrated in human Tenon's capsule fibroblasts. Expand
Natural forms of vitamin E: metabolism, antioxidant, and anti-inflammatory activities and their role in disease prevention and therapy.
  • Q. Jiang
  • Chemistry, Medicine
  • Free radical biology & medicine
  • 2014
TLDR
This review focuses on non-αT forms of vitamin E with respect to their metabolism, anti-inflammatory effects and mechanisms, and in vivo efficacy in preclinical models as well as human clinical intervention studies. Expand
Vitamin E therapy beyond cancer: Tocopherol versus tocotrienol.
TLDR
An update on vitamin E therapeutic potentials, protective effects and modes of action beyond cancer, with comparison of tocopherols against tocotrienols. Expand
New perspectives on vitamin E: γ-tocopherol and carboxyethylhydroxychroman metabolites in biology and medicine
TLDR
A nascent body of epidemiological data suggests that gamma-tocopherol is a better negative risk factor for certain types of cancer and myocardial infarction than is a alpha-tocypes, and argues for thorough experimental and epidemiological reappraisal of desmethyl tocopherols, especially within the contexts of cardiovascular disease and cancer biology. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 142 REFERENCES
The role of metabolism in the antioxidant function of vitamin E.
  • D. Liebler
  • Chemistry, Medicine
  • Critical reviews in toxicology
  • 1993
TLDR
The antioxidant chemistry of alpha-tocopherol is described and the experimental evidence for the linkage ofalpha-tocopherylhydroquinone turnover to cellular metabolism through redox cycles is evaluated. Expand
Absorption, transport and metabolism of vitamin E.
  • C. Drevon
  • Biology, Medicine
  • Free radical research communications
  • 1991
TLDR
Clinical evidence from heavy drinkers and from experimental work in rats suggests that alcohol may increase oxidation of alpha-tocopherol, causing reduced tissue concentrations ofAlpha-Tocopherol. Expand
Tocopherol‐mediated peroxidation of lipoproteins: implications for vitamin E as a potential antiatherogenic supplement
  • J. Upston, A. Terentis, R. Stocker
  • Biology, Medicine
  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 1999
TLDR
The benefits of vitamin E supplementation alone or together with other antioxidants that work in concert with α‐TOH in ameliorating lipoprotein lipid peroxidation in the artery wall and, hence, atherosclerosis are discussed. Expand
Affinity for α‐tocopherol transfer protein as a determinant of the biological activities of vitamin E analogs
TLDR
The affinity of vitamin E analogs for αTTP is one of the critical determinants of their biological activity, and there was a linear relationship between the relative affinity and the known biological activity obtained from the rat resorption‐gestation assay. Expand
Gamma-tocopherol detoxification of nitrogen dioxide: superiority to alpha-tocopherol.
TLDR
A fundamental difference in the chemical reactivities of alpha-tocopherol and gamma-tociperol with nitrogen dioxide (NO2), which leads to the formation of a nitrosating agent from alpha-tropopherol, but not from gamma-ocopherol is described, which suggests the superiority of gamma-ococopherol in a mammalian biological assay and a role for endogenous NO production in promotion of neoplastic transformation. Expand
Antioxidant reactions of vitamin E in the perfused rat liver: product distribution and effect of dietary vitamin E supplementation.
  • A. Ham, D. Liebler
  • Chemistry, Medicine
  • Archives of biochemistry and biophysics
  • 1997
TLDR
These data provide the first simultaneous documentation of TH antioxidant reactions and antioxidant effects in an intact organ system during oxidative stress. Expand
Vitamin E as an antioxidant in vitro and in vivo.
TLDR
Vitamin E and total lipid-soluble, chain-breaking antioxidant concentrations in some normal and cancerous tissues have been measured and a number of unresolved problems relating to the action of vitamin E in vivo are discussed. Expand
γ-Tocopherol traps mutagenic electrophiles such as NOx and complements α-tocopherol: Physiological implications
Peroxynitrite, a powerful mutagenic oxidant and nitrating species, is formed by the near diffusion-limited reaction of ·NO and O2⨪ during activation of phagocytes. Chronic inflammation induced by… Expand
alpha-tocopherol inhibits aggregation of human platelets by a protein kinase C-dependent mechanism.
TLDR
It is found that platelet incorporation of alpha-tocopherol at levels attained with oral supplementation is associated with inhibition of platelet aggregation through a PKC-dependent mechanism, which may represent one potential mechanism for the observed beneficial effect ofalpha-tocyperol in preventing the development of coronary artery disease. Expand
alpha-tocopherol inhibits the respiratory burst in human monocytes. Attenuation of p47(phox) membrane translocation and phosphorylation.
TLDR
The results show that alpha-tocopherol inhibits O-2 production by human adherent monocytes by impairing the assembly of the NADPH-oxidase and suggest that the inhibition of phosphorylation and translocation of the cytosolic factor p47(phox) results from a decrease in PKC activity. Expand
...
1
2
3
4
5
...