Vitamin E: action, metabolism and perspectives

@article{Herrera2010VitaminEA,
  title={Vitamin E: action, metabolism and perspectives},
  author={Emilio Herrera and Coral Barbas},
  journal={Journal of Physiology and Biochemistry},
  year={2010},
  volume={57},
  pages={43-56}
}
  • E. Herrera, C. Barbas
  • Published 1 March 2001
  • Chemistry, Medicine
  • Journal of Physiology and Biochemistry
Natural vitamin E includes four tocopherols and four tocotrienols. RRR-α-tocopherol is the most abundant form in nature and has the highest biological activity. Although vitamin E is the main lipid-soluble antioxidant in the body, not all its properties can be assigned to this action. As antioxidant, vitamin E acts in cell membranes where prevents the propagation of free radical reactions, although it has been also shown to have pro-oxidant activity. Non-radical oxidation products are formed by… Expand
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References

SHOWING 1-10 OF 95 REFERENCES
Absorption, transport and metabolism of vitamin E.
  • C. Drevon
  • Biology, Medicine
  • Free radical research communications
  • 1991
TLDR
Clinical evidence from heavy drinkers and from experimental work in rats suggests that alcohol may increase oxidation of alpha-tocopherol, causing reduced tissue concentrations ofAlpha-Tocopherol. Expand
Vitamin E: non-antioxidant roles.
Vitamin E was originally considered a dietary factor of animal nutrition especially important for normal reproduction. The significance of vitamin E has been subsequently proven as a radical chain… Expand
Vitamin E in human low-density lipoprotein. When and how this antioxidant becomes a pro-oxidant.
TLDR
It is proposed that perodixation is propagated within lipoprotein particles by reaction of the vitamin E radical with polyunsaturated fatty acid moieties in the lipid, which explains how reagents which reduce the alpha-tocopheroxyl radical strongly inhibit lipid peroxidation in vitamin E-containing LDL. Expand
Vitamin E in Health and Disease
TLDR
Analysis and Distribution of Vitamin E in Vegetable Oils and Foods, Alan J. Sheppard, John L. Weihrauch, and Jean A. Pennington Animals and Humans Absorption, Transport and Delivery to Tissues, Maret G. Traber, William Cohn, and David P. R. Draper Effects of ss-Carotene and Related Caritenoids on Vitamin E. Expand
Antioxidant and prooxidant activity of alpha-tocopherol in human plasma and low density lipoprotein.
TLDR
The results indicate that the level of oxidative stress and concentration of co-antioxidants, such as ascorbate, capable of regenerating alpha-tocopherol in the oxidizing lipoprotein particle, appear to represent major factors determining alpha-ocopherol activity towards oxidation both in human plasma and LDL. Expand
Specific Cellular Responses to α-Tocopherol
In the last 10 years precise cellular functions of alpha-tocopherol, some of which are independent of its antioxidant/radical-scavenging ability, have been revealed. Absorption of alpha-tocopherol… Expand
Effect of oral supplementation with D-alpha-tocopherol on the vitamin E content of human low density lipoproteins and resistance to oxidation.
TLDR
It is shown that in humans the oxidation resistance of LDL can be increased by vitamin E supplementation and the association was seen between levels of carotenoids and vitamin E in plasma and LDL. Expand
The chemistry and antioxidant properties of tocopherols and tocotrienols
TLDR
Some possible reasons for the observed differences between the tocopherols (α-, β-, γ-, and δ-) in relation to their interactions with the important chemical species involved in lipid peroxidation, specifically trace metal ions, singlet oxygen, nitrogen oxides, and antioxidant synergists are highlighted. Expand
Oxidants and antioxidants in atherogenesis. An appraisal.
TLDR
There are numerous contributing factors that need to be studied and understood before antioxidant therapy becomes an option for the treatment for cardiovascular diseases. Expand
Effect of dietary supplementation with alpha-tocopherol on the oxidative modification of low density lipoprotein.
TLDR
The effect of dietary supplementation with alpha-tocopherol on the time course of copper-catalyzed oxidation of LDL was tested in a randomized placebo-controlled single-blind study and did not result in any side effects or exert an adverse effect on the plasma lipid and lipoprotein profile. Expand
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