Vitamin E: Emerging aspects and new directions

@article{Galli2017VitaminEE,
  title={Vitamin E: Emerging aspects and new directions},
  author={F. Galli and A. Azzi and M. Birringer and J. Cook‐Mills and M. Eggersdorfer and J. Frank and G. Cruciani and S. Lorkowski and N. {\"O}zer},
  journal={Free Radical Biology and Medicine},
  year={2017},
  volume={102},
  pages={16–36}
}
Abstract The discovery of vitamin E will have its 100th anniversary in 2022, but we still have more questions than answers regarding the biological functions and the essentiality of vitamin E for human health. Discovered as a factor essential for rat fertility and soon after characterized for its properties of fat‐soluble antioxidant, vitamin E was identified to have signaling and gene regulation effects in the 1980s. In the same years the cytochrome P‐450 dependent metabolism of vitamin E was… Expand
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References

SHOWING 1-10 OF 343 REFERENCES
Analytical strategies to assess the functional metabolome of vitamin E.
TLDR
The present review collects the available information on the most relevant analytical strategies employed to assess the status and metabolism of vitamin E in humans as well as in other model systems. Expand
Present trends in vitamin E research
TLDR
Besides vitamin E signaling, attention will be given to tocotrienols as one of the emerging topics in vitamin E research and a critical re‐examination of the most recent clinical trials will be provided together with the potential use of vitamin E in disease prevention and therapy. Expand
Vitamin E: the shrew waiting to be tamed.
TLDR
Emerging knowledge on vitamin E is compiled here with the perspective to unravel the molecular mechanisms that could more likely explain the essentiality of the vitamin than its ability to scavenge free radicals. Expand
Beyond vitamin E supplementation: an alternative strategy to improve vitamin E status.
  • J. Frank
  • Chemistry, Medicine
  • Journal of plant physiology
  • 2005
TLDR
The findings from these studies show that the tested dietary phenolic compounds increase vitamin E concentrations through different mechanisms and, thus, have the potential to improve vitamin E status without the use of vitamin E supplements. Expand
Vitamin E: the enigmatic one!
  • W. Blaner
  • Biology, Medicine
  • Journal of Lipid Research
  • 2013
TLDR
The biology of vitamin E and its role in human cardiovascular disease will be considered in the two reviews that comprise this edition of the Thematic Review Series on fat-soluble vitamins. Expand
Regulatory metabolites of vitamin E and their putative relevance for atherogenesis
TLDR
The controversial role of vitamin E as a preventive agent against atherosclerosis is summarized and a role of these long-chain metabolites of α-tocopherol, which are formed as catabolic intermediate products in the liver and occur in human plasma are speculated. Expand
Vitamin E biotransformation in humans.
TLDR
This chapter will provide an overview of the known and less known steps of vitamin E biotransformation in humans, and particular attention will be given to the description of the formation, identification, and functions of Vitamin E metabolites. Expand
Complexity of vitamin E metabolism.
TLDR
The coordinated changes involved in the hepatic metabolism of vitamin E provide an effective physiological pathway to protect tissues against the excessive accumulation of, in particular, non-α-tocopherol forms. Expand
Isoforms of vitamin E differentially regulate inflammation.
TLDR
This review will discuss regulation of inflammation by vitamin E, including alternative interpretations of previous studies in the literature with regards to vitamin E isoforms, as well as reported unrecognized properties of isoforms of vitamin E. Expand
Vitamin E, antioxidant and nothing more.
TLDR
The claim is made that alpha-tocopherol's major vitamin function, if not only function, is that of a peroxyl radical scavenger, which is to maintain the integrity of long-chain polyunsaturated fatty acids in the membranes of cells and thus maintain their bioactivity. Expand
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