Vitamin E, nuclear receptors and xenobiotic metabolism.

  title={Vitamin E, nuclear receptors and xenobiotic metabolism.},
  author={Maret G Traber},
  journal={Archives of biochemistry and biophysics},
  volume={423 1},
  • Maret G Traber
  • Published 2004 in Archives of biochemistry and biophysics
Supplemental vitamin E (alpha-tocopherol) is taken daily by more than 35 million people in the US. Following absorption and liver uptake, the fate of vitamin E is largely unknown. Of potential importance are recent clinical studies that have reported adverse effects of vitamin E that may be directly related to its hepatic metabolism. In an in vitro system, both vitamin E and rifampicin, a known stimulator of xenobiotic metabolism, activated the pregnane X receptor (PXR), an orphan nuclear… CONTINUE READING


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