Vitamin D3 up-regulated protein-1 regulates collagen expression in mesangial cells.

BACKGROUND Hyperglycemia is a known risk factor in the pathogenesis of nephropathy, and collagen accumulation due to an increase reactive oxygen species (ROS) has been suspected to be one of the reasons for high glucose-mediated diseases. However, molecular mechanisms that connect glucose stimulation, oxidative stress, and collagen induction are unknown… CONTINUE READING