Vitamin D3 polyunsaturated side-chain analogues (EB1089, GS1590) and the 20-epi-vitamin D3 analogue CB1393 suppress parathyroid hormone secretion and mRNA level in bovine parathyroid cells.

@article{Segersten2004VitaminDP,
  title={Vitamin D3 polyunsaturated side-chain analogues (EB1089, GS1590) and the 20-epi-vitamin D3 analogue CB1393 suppress parathyroid hormone secretion and mRNA level in bovine parathyroid cells.},
  author={Ulrika Segersten and Pernille Kaae Holm and Lise Binderup and G{\"o}ran {\AA}kerstr{\"o}m and Per Hellman and Gunnar Westin},
  journal={The Journal of steroid biochemistry and molecular biology},
  year={2004},
  volume={88 3},
  pages={289-94}
}
Several vitamin D analogues, with reduced hypercalcemic and hyperphosphatemic toxicity at therapeutic dosages, are in clinical use for prevention and treatment of secondary hyperparathyroidism (HPT) in chronic renal failure. We have performed a first in vitro evaluation of five vitamin D analogues displaying less calcemic activity in normal rats, considerably more antiproliferative ability and higher transcription activation potential than 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)), with the… CONTINUE READING