Vitamin D3 inhibits fatty acid synthase expression by stimulating the expression of long‐chain fatty‐acid‐CoA ligase 3 in prostate cancer cells

@article{Qiao2004VitaminDI,
  title={Vitamin D3 inhibits fatty acid synthase expression by stimulating the expression of long‐chain fatty‐acid‐CoA ligase 3 in prostate cancer cells},
  author={Shengjun Qiao and Pentti Tuohimaa},
  journal={FEBS Letters},
  year={2004},
  volume={577}
}
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18 Citations
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18 Citations

Expression and vitamin D3 regulation of long-chain fatty-acid-CoA ligase 3 in human prostate cancer cells.
Vitamin D regulation of energy metabolism in cancer
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Mechanisms involved in energy metabolism regulation are an emerging area in which vitamin D may inhibit multiple stages of cancer progression, as well as oxidative stress protection, as it is closely associated with energy metabolism.
Active vitamin D supplementation alleviates initiation and progression of nonalcoholic fatty liver disease by repressing the p53 pathway.
Remodeling of phospholipid composition in colon cancer cells by 1α,25(OH)2D3 and its analogs
Therapeutic and toxicologic evaluation of anti-lipogenic agents in cancer cells compared with non-neoplastic cells.
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DNA fragmentation analysis suggests that FASN inhibitors induced apoptotic DNA damage in retinoblastoma cells, suggesting that FasN inhibition can be an effective strategy in ret inoblastomas therapy.
Soluble fatty acid synthase relates to bone biomarkers in prepubertal children
TLDR
Circulating soluble FASN relates to both adipose tissue and bone biomarkers in prepubertal children, with associations that are dependent on Vit D concentrations, which suggest that FASn may participate in the crosstalk between fat and bone metabolism.
Cerulenin-mediated apoptosis is involved in adenine metabolic pathway.
The lipogenesis pathway as a cancer target.
  • H. Abramson
  • Biology, Chemistry
    Journal of medicinal chemistry
  • 2011
TLDR
The objectives of this Perspective are to provide an overview of the lipogenic process, primarily as it relates to these three enzymes, examine the relationship of lipogenesis to tumor biology, and outline the opportunities and prospects for targeting the process in the search for new anticancer drugs.
Chemopreventive Effects of Dietary Selenium and Soy Isoflavones in a Mouse Model of Prostate Cancer
TLDR
This study identifies a previously unknown effect of isoflavones in the upregulation of FOXO expression and confirms previous studies of is oflavones’anticancer effects.
Global liver proteome analysis using iTRAQ labeling quantitative proteomic technology to reveal biomarkers in mice exposed to perfluorooctane sulfonate (PFOS).
TLDR
Insight is provided into the molecular mechanism and biomarkers for PFOS-induced effects of liver proteome characterization in mice exposed to perfluorooctane sulfonate.
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References

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Inhibition of fatty acid synthase expression by 1α,25-dihydroxyvitamin D3 in prostate cancer cells
Selective activation of the fatty acid synthesis pathway in human prostate cancer
TLDR
It is reported that in prostate cancer fatty acid synthase expression is up‐regulated at the mRNA level together with other enzymes of the same metabolic pathway, pointing to selective activation of the fatty acid synthesis pathway and suggesting a shift in the balance of lipogenic gene expression in a subgroup of prostate cancers.
RNA interference-mediated silencing of the fatty acid synthase gene attenuates growth and induces morphological changes and apoptosis of LNCaP prostate cancer cells.
TLDR
Silencing of the FASE gene by RNAi significantly inhibited LNCaP cell growth and ultimately resulted in induction of apoptosis, indicating that RNAi opens new avenues toward the study of the role of FASE overexpression in tumor cells and provides an interesting and selective alternative in the development of antineoplastic therapy.
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Overexpression of fatty acid synthase is an early and common event in the development of prostate cancer
TLDR
Findings indicate that increased FAS expression is one of the earliest and most common events in the development of prostate cancer, suggesting that FAS may be used as a general prostate cancer marker and that antineoplastic therapy based on FAS inhibition may be an option for chemoprevention or curative treatment for nearly all prostate cancers.
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