Vitamin D3 down-regulates monocyte TLR expression and triggers hyporesponsiveness to pathogen-associated molecular patterns.

@article{Sadeghi2006VitaminDD,
  title={Vitamin D3 down-regulates monocyte TLR expression and triggers hyporesponsiveness to pathogen-associated molecular patterns.},
  author={Kambis Sadeghi and Barbara Wessner and Ute Laggner and Martin Ploder and Dietmar Tamandl and Josef Friedl and Ullrich Z{\"u}gel and Andreas Steinmeyer and Arnold Pollak and Erich G. Roth and G Boltz-nitulescu and Andreas Spittler},
  journal={European journal of immunology},
  year={2006},
  volume={36 2},
  pages={361-70}
}
Toll-like receptors (TLR) represent an ancient front-line defence system that enables the host organism to sense the presence of microbial components within minutes. As inducers of inflammation, TLR act as important triggers of distinct entities such as sepsis or autoimmune disease exacerbation. We report here that vitamin D3 [1alpha,25-dihydroxycholecalciferol, 1,25(OH)(2)D3] suppresses the expression of TLR2 and TLR4 protein and mRNA in human monocytes in a time- and dose-dependent fashion… CONTINUE READING
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