Vitamin D3—implications for brain development

@article{Mcgrath2004VitaminDF,
  title={Vitamin D3—implications for brain development},
  author={J J Mcgrath and François F{\'e}ron and Thomas H. J. Burne and Alan Mackay-Sim and Darryl Walter Eyles},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  year={2004},
  volume={89–90},
  pages={557-560}
}
  • J. Mcgrath, F. Féron, D. Eyles
  • Published 1 May 2004
  • Biology, Medicine
  • The Journal of Steroid Biochemistry and Molecular Biology

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References

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1,25(OH)2 vitamin D3 sites of action in the brain

TLDR
The extensive distribution of target neurons suggests that 1,25(OH)2 vitamin D3 regulates the production of several aminergic and peptidergic messengers, and influences the activity of certain endocrine-autonomic, sensory and motor systems.

1,25-Dihydroxyvitamin D3 Induction of Nerve Growth Factor in L929 Mouse Fibroblasts: Effect of Vitamin D Receptor Regulation and Potency of Vitamin D3 Analogs1.

TLDR
The VDR in L929 cells is characterized and it is shown that 1,25-(OH)2D3 and its less calcemic analogs induce NGF, and up-regulation of VDR abundance enhanced NGF induction.

Vitamin D receptor expression in the embryonic rat brain

TLDR
It is shown that the well-described increase in apoptotic cells and decrease in mitotic cells during development correlates with the appearance of the VDR in brain tissue and the timing of its appearance with two vital developmental events, apoptosis and mitosis.

1,25‐Dihydroxyvitamin D3 is a potent inducer of nerve growth factor synthesis

TLDR
1,25‐(OH)2D3 could represent one of the serum factors that might contribute to the regulation of the NGF gene in vitro and possibly in vivo and is shown to increase in a dose‐dependent manner the cellular pool of NGF mRNA in murine L‐929 fibroblasts cultured in a serum‐free medium.

Vitamin D: the neglected neurosteroid?