Vitamin D3—implications for brain development

  title={Vitamin D3—implications for brain development},
  author={J J Mcgrath and François F{\'e}ron and Thomas H. J. Burne and Alan Mackay-Sim and Darryl Walter Eyles},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  • J. McgrathF. Féron D. Eyles
  • Published 1 May 2004
  • Biology, Medicine
  • The Journal of Steroid Biochemistry and Molecular Biology


The vitamin D endocrine systems plays a critical role in calcium and phosphate homeostasis and many of these nonclassic responses have suggested a number of therapeutic applications for 1,25(OH)(2)D(3) and its analogs.

Vitamin D

The vitamin D endocrine systems plays a critical role in calcium and phosphate homeostasis and recent studies with VDR-ablated mice confirm that the most critical role of 1,25(OH)2D3 is the activation of genes that control intestinal calcium transport.

Molecular Link between Vitamin D and Cancer Prevention

It is suggested that countries where cancer is on the rise—yet where sunlight and, hence, vitamin D may be easily acquired—adopt awareness, education and implementation strategies to increase supplementation with vitamin D in all age groups as a preventive measure to reduce cancer risk and prevalence.

Neurosteroid hormone vitamin D and its utility in clinical nutrition

Clinical and experimental evidence of the role of vitamin D in normal and pathological brain functions are discussed, and the relative importance ofitamin D-modulated brain mechanisms at different stages of life are analyzed.

Vitamin D interacts with Esr1 and Igf1 to regulate molecular pathways relevant to Alzheimer’s disease

Underlies the multiplicity of action of this potent neurosteroid in an aging and AD-like brain and translates into improved learning and memory performance and a decrease in amyloid plaques and astrogliosis in Tg animals.

Vitamin D and hippocampal development-the story so far

  • A. Lardner
  • Biology, Psychology
    Front. Mol. Neurosci.
  • 2015
A small number of studies, mostly in vitro, point to a role for vitamin D in differentiation and development of hippocampal neurons, and limited evidence that supplementation with vitamin D following a period of deprivation is capable of restoring cellular activity and later function.

Neonatal vitamin D and childhood brain tumor risk

Any associations of neonatal vitamin D with CBT may be birth weight‐specific, suggesting the possible involvement of insulin‐like growth factor 1, circulating levels of which have been associated with vitamin D and accelerated fetal growth.

Vitamin D and the nervous system

Compared to the vehicle-treated control animals, the Vitamin D-treated mice demonstrated reduced severity of PTZ-induced seizures (longer latency, shorter duration and lower mortality).

Circulating 25-Hydroxyvitamin D3 in Pregnancy and Infant Neuropsychological Development

Higher circulating concentration of maternal 25(OH)D3 in pregnancy was associated with improved mental and psychomotor development in infants, and a positive linear relationship was found.



1,25(OH)2 vitamin D3 sites of action in the brain

The extensive distribution of target neurons suggests that 1,25(OH)2 vitamin D3 regulates the production of several aminergic and peptidergic messengers, and influences the activity of certain endocrine-autonomic, sensory and motor systems.

1,25-Dihydroxyvitamin D3 Induction of Nerve Growth Factor in L929 Mouse Fibroblasts: Effect of Vitamin D Receptor Regulation and Potency of Vitamin D3 Analogs1.

The VDR in L929 cells is characterized and it is shown that 1,25-(OH)2D3 and its less calcemic analogs induce NGF, and up-regulation of VDR abundance enhanced NGF induction.

Vitamin D receptor expression in the embryonic rat brain

It is shown that the well-described increase in apoptotic cells and decrease in mitotic cells during development correlates with the appearance of the VDR in brain tissue and the timing of its appearance with two vital developmental events, apoptosis and mitosis.

1,25‐Dihydroxyvitamin D3 is a potent inducer of nerve growth factor synthesis

1,25‐(OH)2D3 could represent one of the serum factors that might contribute to the regulation of the NGF gene in vitro and possibly in vivo and is shown to increase in a dose‐dependent manner the cellular pool of NGF mRNA in murine L‐929 fibroblasts cultured in a serum‐free medium.

Vitamin D: the neglected neurosteroid?