Vitamin D3: an ever green molecule.

@article{diRosa2013VitaminDA,
  title={Vitamin D3: an ever green molecule.},
  author={Michele di Rosa and Lucia Malaguarnera and Anna Elisa Nicolosi and Cristina Sanfilippo and Clorinda Mazzarino and Piero Pavone and Massimiliano Berretta and Stefano Cosentino and Bruno Cacopardo and Marilia Rita Pinzone and Giuseppe Nunnari},
  journal={Frontiers in bioscience},
  year={2013},
  volume={5},
  pages={
          247-60
        }
}
Vitamin D3 is a key regulator of vertebrates homeostasis. It is synthesized from the precursor 7-dehydrocholesterol upon UVB exposure in the skin and then hydrolyzed in the liver in position 25, to be finally converted into its active form, 1,25-dihydroxyvitamin D (1,25(OH)2D or calcitriol), in the kidneys. The biological activity of this molecule depends on its binding to the nuclear receptor VDR, which binds VDRE once complexed with RXR-alpha. Despite being present in different types of food… Expand
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