Vitamin D to prevent exacerbations of COPD: systematic review and meta-analysis of individual participant data from randomised controlled trials

@article{Jolliffe2019VitaminDT,
  title={Vitamin D to prevent exacerbations of COPD: systematic review and meta-analysis of individual participant data from randomised controlled trials},
  author={David A. Jolliffe and Lauren Greenberg and Richard L Hooper and Carolien Mathyssen and Rachida Rafiq and Renate T. de Jongh and Carlos A. Camargo and Christopher J Griffiths and Wim Janssens and Adrian R. Martineau},
  journal={Thorax},
  year={2019},
  volume={74},
  pages={337 - 345}
}
Background Randomised controlled trials (RCTs) of vitamin D to prevent COPD exacerbations have yielded conflicting results. Individual participant data meta-analysis could identify factors that explain this variation. Methods PubMed, Embase, the Cochrane Central Register of Controlled Trials and Web of Science were searched from inception up to and including 5 October 2017 to identify RCTs of vitamin D supplementation in patients with COPD that reported incidence of acute exacerbations… 
Vitamin D supplementation to prevent acute respiratory infections: individual participant data meta-analysis.
TLDR
Vitamin D supplementation was safe, and it protected against ARIs overall, and incorporation of additional IPD from ongoing trials in the field has the potential to increase statistical power for analyses of secondary outcomes.
Adjunctive vitamin D in tuberculosis treatment: meta-analysis of individual participant data
TLDR
A meta-analysis of individual participant data from clinical trials reports that adjunctive vitamin D accelerates sputum culture conversion in patients with multidrug-resistant tuberculosis, but not in those with drug-sensitive disease.
Effect of Monthly Vitamin D Supplementation on Preventing Exacerbations of Asthma or Chronic Obstructive Pulmonary Disease in Older Adults: Post Hoc Analysis of a Randomized Controlled Trial
TLDR
Although monthly vitamin D supplementation had no overall impact on risk of exacerbations of asthma or COPD, there was evidence of a probable benefit among those with severe vitamin D deficiency.
Effects of Nutritional Interventions in Individuals with Chronic Obstructive Lung Disease: A Systematic Review of Randomized Controlled Trials
TLDR
Increasing intake of fruits and vegetables over prolonged periods might have positive effects on lung function in individuals with COPD, although with some mixed results.
Impact of vitamin D on spirometry findings and quality of life in patients with chronic obstructive pulmonary disease: a randomized, double-blinded, placebo-controlled clinical trial
TLDR
The current study shows that consumption of 50,000 IU vitamin D3, as a convenient supplementation in a daily diet, is able to increase quality of life in patients with COPD.
Critical Appraisal of Large Vitamin D Randomized Controlled Trials
TLDR
The recent large vitamin D RCTs did not challenge the beneficial effects of vitamin D regarding rickets and osteomalacia, that therefore continue to provide the scientific basis for nutritional vitamin D guidelines and recommendations.
Vitamin D in chronic obstructive pulmonary disease and asthma in Indian population
TLDR
Vitamin D supplementation reduced asthma exacerbations treated with oral corticosteroids when compared with placebo, and differences across subgroups, including baseline 25-hydroxyvitamin D status, did not reach statistical significance.
Comparison of the association between circulating vitamin D3 levels and clinical outcomes in patients with asthma and chronic obstructive pulmonary disease: a prospective observational study.
TLDR
Lower concentrations of plasma 25(OH)D3 contributed to lower HR-QOL in patients with asthma, and were associated with severity and risk of future exacerbations in Patients with COPD.
Association between Vitamin D Supplementation and Mental Health in Healthy Adults: A Systematic Review
TLDR
None of the high-quality studies (assessed using NOS), which evaluated outcomes other than depression, supported the hypothesis that vitamin D supplementation effectively ameliorates mental health issues, while they present conflicting evidence for depression.
Testing for Vitamin D in High-Risk COPD in Outpatient Clinics in Spain: A Cross-Sectional Analysis of the VITADEPOC Study
TLDR
The testing of vitamin D levels in patients with high-risk COPD treated at outpatient respiratory clinics in Spain is infrequent, however, when tested, a severe deficiency is detected in one in four patients.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 43 REFERENCES
Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data
TLDR
Vitamin D supplementation was safe and it protected against acute respiratory tract infection overall and patients who were very vitamin D deficient and those not receiving bolus doses experienced the most benefit.
Prevention of exacerbations in patients with COPD and vitamin D deficiency through vitamin D supplementation (PRECOVID): a study protocol
TLDR
This study will be the first RCT aimed at the effects of vitamin D supplementation on exacerbation rate in vitamin D deficient COPD patients, and in contrast to earlier studies that used infrequent dosing regimens, this trial will study effects of a weekly dose ofitamin D supplementation.
Effects of Vitamin D Intake on FEV1 and COPD Exacerbation: A Randomized Clinical Trial Study
TLDR
Vitamin D intake decreased COPD exacerbation and improved FEV1 in the patients with severe and very severe COPD, and it is suggested that baseline serum vitamin D levels will be recorded in similar studies and the effect of vitamin D intake will evaluated regarding the baseline serumitamin D levels.
High Doses of Vitamin D to Reduce Exacerbations in Chronic Obstructive Pulmonary Disease
TLDR
High-dose vitamin D supplementation in a sample of patients with COPD did not reduce the incidence of exacerbations and a post hoc analysis showed that in participants with severe vitamin D deficiency at baseline, supplementation may reduce exacerbations.
No association of 25-hydroxyvitamin D with exacerbations in primary care patients with COPD.
TLDR
This longitudinal study in a real-world COPD population that carefully minimized misclassification of exacerbations and the influence of confounding did not show an association of 25-hydroxyvitamin D with exacerbation and mortality.
Effects of daily vitamin D supplementation on respiratory muscle strength and physical performance in vitamin D-deficient COPD patients: a pilot trial
TLDR
Vitamin D supplementation did not affect (respiratory) muscle strength or physical performance in this pilot trial in vitamin D-deficient COPD patients, and primary outcomes did not differ between the groups after 6 months.
Severe vitamin D deficiency is associated with frequent exacerbations and hospitalization in COPD patients
TLDR
In COPD patients severe vitamin D deficiency was related to more frequent disease exacerbations and hospitalization during the year previous to the measurement of vitamin D, independent of patients’ characteristics and comorbidities.
Vitamin D levels and risk of acute exacerbations of chronic obstructive pulmonary disease: a prospective cohort study.
TLDR
In patients with severe COPD, baseline 25(OH)D levels are not predictive of subsequent AECOPD, and these levels were measured at baseline on entry to a 1-year study designed to determine if daily azithromycin decreased the incidence of A ECOPD.
...
1
2
3
4
5
...