Vitamin D supplementation for the treatment of COVID-19: a living systematic review.

  title={Vitamin D supplementation for the treatment of COVID-19: a living systematic review.},
  author={Julia Kristin Stroehlein and J Wallqvist and Claire Iannizzi and Agata Mikołajewska and Maria-Inti Metzendorf and Carina Benstoem and Patrick Meybohm and Marie Becker and Nicole Skoetz and Miriam Songa Stegemann and Vanessa Piechotta},
  journal={The Cochrane database of systematic reviews},
BACKGROUND The role of vitamin D supplementation as a treatment for COVID-19 has been a subject of considerable discussion. A thorough understanding of the current evidence regarding the effectiveness and safety of vitamin D supplementation for COVID-19 based on randomised controlled trials is required. OBJECTIVES To assess whether vitamin D supplementation is effective and safe for the treatment of COVID-19 in comparison to an active comparator, placebo, or standard of care alone, and to… 
Association between Vitamin D Status and Risk of Developing Severe COVID-19 Infection: A Meta-Analysis of Observational Studies
A potential increased risk of developing severe COVID-19 infection among patients with low vitamin D levels is found and plausible biological mechanisms supporting the role of vitamin D in CO VID-19 severity are found.
Previous Vitamin D Supplementation and Morbidity and Mortality Outcomes in People Hospitalised for COVID19: A Cross-Sectional Study
An association between vitamin D supplementation before hospital admission and death and/or IMV in subjects admitted for COVID-19 did not find an association and the age and the burden of age-associated comorbidities were independently associated with the in-hospital events.
Vitamin D and COVID-19: An Overview of Recent Evidence
There are some conflicting results reported, but the consensus is that vitamin D has a host of immunomodulatory effects which may be beneficial in the context of COVID-19 and that low levels of vitamin D can result in dysfunction of crucial antimicrobial effects, potentially contributing to poor prognosis.
Investigating the Relationship between Vitamin D and Persistent Symptoms Following SARS-CoV-2 Infection
It is suggested that persistent fatigue and reduced exercise tolerance following COVID-19 are independent of vitamin D, as well as the measures of ongoing ill-health assessed in the study.
Effect of a Single High-Dose Vitamin D3 on the Length of Hospital Stay of Severely 25-Hydroxyvitamin D-Deficient Patients with COVID-19
A dose of 200.000 IU of vitamin D3 did not significantly reduce the length of hospital stay of patients with severe 25-hydroxyvitamin D deficiency and COVID-19 and no significant difference was observed in the median interquartile range of length ofospital stay between the vitamin D2 group and the placebo group.
The Role of Herbal and Nutritional Treatments in the Fight against COVID-19 and Other Respiratory Tract Infections
Studies assessing the roles of Chinese traditional medicine and nutrition in upper respiratory infections, including COVID-19, are reviewed, with promising findings reported when medical treatments were complemented with nutritional interventions.
Sars-Cov-2 antibody titer 3 months post-vaccination is affected by age, gender, smoking and vitamin D.
Age, male sex and smoking negatively affects antibody titer while 25(OH)D is associated with increased Sars-Cov-2 antibody titers, and DHEAS, an aging marker, was not associated with the antibodies.
Normal T and B Cell Responses Against SARS-CoV-2 in a Family With a Non-Functional Vitamin D Receptor: A Case Report
It is demonstrated that vitamin D signaling was dispensable for mounting an efficient adaptive immune response against SARS-CoV-2 in this family and questioned a central role of vitamin D in the generation of adaptive immunity against Sars-Cov-2.
Beneficial effects of novel aureobasidium pullulans strains produced beta-1,3-1,6 glucans on interleukin-6 and D-dimer levels in COVID-19 patients; results of a randomized multiple-arm pilot clinical study
The beneficial effects of beta glucans derived from two strains AFO-202 and N-163 of a black yeast Aureobasidium pullulans on the biomarkers for cytokine storm and coagulopathy in COVID-19 patients are reported.
Triple jeopardy in ageing: COVID-19, co-morbidities and inflamm-ageing
Covid-19 endangers lives, has disrupted normal life, changed the way medicine is practised and is likely to alter our world for the foreseeable future. Twenty months on since the presumptive first