Vitamin D supplementation for the treatment of COVID-19: a living systematic review.

@article{Stroehlein2021VitaminDS,
  title={Vitamin D supplementation for the treatment of COVID-19: a living systematic review.},
  author={Julia Kristin Stroehlein and Julia Wallqvist and Claire Iannizzi and Agata Mikołajewska and Maria-Inti Metzendorf and Carina Benstoem and Patrick Meybohm and Marie Becker and Nicole Skoetz and Miriam Songa Stegemann and Vanessa Piechotta},
  journal={The Cochrane database of systematic reviews},
  year={2021},
  volume={5},
  pages={
          CD015043
        }
}
BACKGROUND The role of vitamin D supplementation as a treatment for COVID-19 has been a subject of considerable discussion. A thorough understanding of the current evidence regarding the effectiveness and safety of vitamin D supplementation for COVID-19 based on randomised controlled trials is required. OBJECTIVES To assess whether vitamin D supplementation is effective and safe for the treatment of COVID-19 in comparison to an active comparator, placebo, or standard of care alone, and to… 

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Although the current meta-analysis findings indicate potential role of vitamin D in improving COVID-19 severity in hospitalized patients, more robust data from randomized controlled trials are needed to substantiate its effects on mortality.

Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data

Vitamin D supplementation was safe and it protected against acute respiratory tract infection overall and patients who were very vitamin D deficient and those not receiving bolus doses experienced the most benefit.

Vitamin D deficiency aggravates COVID-19: systematic review and meta-analysis

A positive association between vitamin D deficiency and the severity of the disease was observed and was identified that severe cases of COVID-19 present 64% (or 1.64; 95% CI = 1.30–2.09) moreitamin D deficiency compared with mild cases.

Short term, high-dose vitamin D supplementation for COVID-19 disease: a randomised, placebo-controlled, study (SHADE study)

Greater proportion of vitamin D-deficient individuals with SARS-CoV-2 infection turned Sars-Cov-2 RNA negative with a significant decrease in fibrinogen on high-dose cholecalciferol supplementation.

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Most of the articles reviewed showed that blood vitamin D status can determine the risk of being infected with COVID-19, seriousness of COVID -19, and mortality from CO VID-19.

Vitamin D supplementation to prevent acute respiratory infections: individual participant data meta-analysis.

Vitamin D supplementation was safe, and it protected against ARIs overall, and incorporation of additional IPD from ongoing trials in the field has the potential to increase statistical power for analyses of secondary outcomes.

COvid-19 and high-dose VITamin D supplementation TRIAL in high-risk older patients (COVIT-TRIAL): study protocol for a randomized controlled trial

COVIT-TRIAL is to the authors' knowledge the first randomized controlled trial testing the effect of vitamin D supplementation on the prognosis of COVID-19 in high-risk older patients.
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