Vitamin D supplementation for the management of knee osteoarthritis: a systematic review of randomized controlled trials

  title={Vitamin D supplementation for the management of knee osteoarthritis: a systematic review of randomized controlled trials},
  author={Salman Hussain and Ambrish Singh and Mohd. Akhtar and Abul Kalam Najmi},
  journal={Rheumatology International},
Conflicting evidence exists concerning the supplementation of vitamin D in knee osteoarthritis condition. This systematic literature review was done to explore the effects of vitamin D supplementation in the management of knee osteoarthritis. Electronic literature search was done in databases like PubMed®, Embase®, and Cochrane CENTRAL from inception to 6th July 2016. The quality of included Randomized Controlled Trials (RCTs) was assessed using Cochrane risk of bias tool. We considered change… 

Nutraceutical supplements in management of pain and disability in osteoarthritis: a systematic review and meta-analysis of randomized clinical trials

It is suggested that nutraceutical supplementation of patients with knee/hip OA may lead to an improvement in pain intensity and physical function.

Effect of vitamin D supplementation on pain and physical function in patients with knee osteoarthritis (OA): an OA Trial Bank protocol for a systematic review and individual patient data (IPD) meta-analysis

This study will be the first IPD meta-analysis to clarify the effect of vitamin D supplementation on clinical symptoms in different subgroups of patients with knee OA, and identify patient-level predictors of treatment response to vitamin D supplements on pain and physical function.

A Meta-Analysis of the Impact of Nutritional Supplementation on Osteoarthritis Symptoms

Curcumin and ginger supplementation can have a favorable impact on knee OA symptoms and other studies are needed to better assess the effects of omega-3 and vitamin D.

Effect of collagen supplementation on osteoarthritis symptoms: a meta-analysis of randomized placebo-controlled trials

The results of this meta-analysis showed that collagen is effective in improving OA symptoms by the decrease of both total WOMAC index and VAS score.

Use of Vitamin D Supplements in Osteoarthritis: An Observational Study in a Tertiary Health Care Facility

Vitamin D supplements have significantly improved serum 25(OH)D levels, PTH, severity grade, and pain score of OA patients and shown improvement in the overall health of Oa patients, emphasizing the place of vitamin D supplements in the management of O a.

Vitamin K and D Status in Patients with Knee Osteoarthritis: An Analytical Cross-sectional Study

It is observed that although with a decreased level of two vitamins, the score of pain significantly increases, the only effective factors in pain score were disease status and the deficiency of vitamin K and D is likely associated with a higher risk of OA.

The Effects Of Vitamin D On Muscle Strength And Functional Status Of The Elderly Patients With Knee Osteoarthritis

Vitamin D deficiency seems to be a factor contributing to pain, muscle weakness, and disability in patients with knee osteoarthritis.

The Role of Vitamin D in Early Knee Osteoarthritis and Its Relationship with Their Physical and Psychological Status

Correlation analysis showed a relationship between serum 25(OH)D, PTH and pain intensity, and social participation, which highlights the relevance of vitamin D in the early diagnosis and prevention of EOA.

Vitamin D deficiency, functional status, and balance in older adults with osteoarthritis

Vitamin D deficiency is associated with worse severity, functional status, and postural balance in patients with OA, indicating a worse functional impairment when compared to individuals with normal vitamin D levels.



The effect of vitamin D supplementation on knee osteoarthritis, the VIDEO study: a randomised controlled trial.

Does Vitamin D Improve Osteoarthritis of the Knee: A Randomized Controlled Pilot Trial

There is a small but statistically significant clinical benefit to vitamin D treatment in patients with knee OA, although it is recommend a long‐term study to determine whether these changes are clinically important and whether they will be sustained with time.

Effect of Vitamin D Supplementation on Tibial Cartilage Volume and Knee Pain Among Patients With Symptomatic Knee Osteoarthritis: A Randomized Clinical Trial.

Among patients with symptomatic knee osteoarthritis and low serum 25-hydroxyvitamin D levels, vitamin D supplementation, compared with placebo, did not result in significant differences in change in MRI-measured tibial cartilage volume or WOMAC knee pain score over 2 years.

Effect of vitamin D supplementation on progression of knee pain and cartilage volume loss in patients with symptomatic osteoarthritis: a randomized controlled trial.

Vitamin D supplementation for 2 years at a dose sufficient to elevate 25-hydroxyvitamin D plasma levels to higher than 36 ng/mL, when compared with placebo, did not reduce knee pain or cartilage volume loss in patients with symptomatic knee OA.

Vitamin D status in patients with knee or hip osteoarthritis in a Mediterranean country

There was a significantly positive association between vitamin D levels and male gender and these findings indicate a large percentage of vitamin D deficient patients with knee or hip OA, which is unexpected considering the high annual insolation in northern Greece.

Low levels of vitamin D and worsening of knee osteoarthritis: results of two longitudinal studies.

The findings indicate that vitamin D status is unrelated to the risk of joint space or cartilage loss in knee OA, and confidence limits in the analyses of vitamin D deficiency were narrow, suggesting that results were not based on insufficient power.

Diffuse Musculoskeletal Pain Is Not Associated With Low Vitamin D Levels or Improved by Treatment With Vitamin D

  • A. WarnerSarah A Arnspiger
  • Medicine
    Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases
  • 2008
Low vitamin D levels are not associated with diffuse musculoskeletal pain, and treatment with vitamin D does not reduce pain in patients with diffuse pain who have lowitamin D levels.

THU0197 The Effects of Vitamin D Levels on Pain Intensity, Muscle Strength and Functional Status of the Elderly Patients with Knee Osteoarthritis

Vitamin D deficiency can be a contributor factor in pain, disability and muscle weakness in patients with knee osteoarthritis, and concomitant vitamin D deficiency should be considered in elderly patients with knees OA.