Vitamin D supplementation for the management of knee osteoarthritis: a systematic review of randomized controlled trials

@article{Hussain2017VitaminDS,
  title={Vitamin D supplementation for the management of knee osteoarthritis: a systematic review of randomized controlled trials},
  author={Salman Hussain and Ambrish Singh and Mohd. Akhtar and Abul Kalam Najmi},
  journal={Rheumatology International},
  year={2017},
  volume={37},
  pages={1489-1498}
}
Conflicting evidence exists concerning the supplementation of vitamin D in knee osteoarthritis condition. This systematic literature review was done to explore the effects of vitamin D supplementation in the management of knee osteoarthritis. Electronic literature search was done in databases like PubMed®, Embase®, and Cochrane CENTRAL from inception to 6th July 2016. The quality of included Randomized Controlled Trials (RCTs) was assessed using Cochrane risk of bias tool. We considered change… 
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TLDR
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The aims of this review are to determine the therapeutic and preventive potential of vitamin D supplementation in KOA and to address the inconsistencies in the results of studies addressing the association and effect of Vitamin D supplementation.
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TLDR
There is a small but statistically significant clinical benefit to vitamin D treatment in patients with knee OA, although a long-term study is needed to determine whether these changes are clinically important and whether they will be sustained with time.
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TLDR
Among patients with symptomatic knee osteoarthritis and low serum 25-hydroxyvitamin D levels, vitamin D supplementation, compared with placebo, did not result in significant differences in change in MRI-measured tibial cartilage volume or WOMAC knee pain score over 2 years.
Effect of vitamin D supplementation on progression of knee pain and cartilage volume loss in patients with symptomatic osteoarthritis: a randomized controlled trial.
TLDR
Vitamin D supplementation for 2 years at a dose sufficient to elevate 25-hydroxyvitamin D plasma levels to higher than 36 ng/mL, when compared with placebo, did not reduce knee pain or cartilage volume loss in patients with symptomatic knee OA.
Vitamin D status in patients with knee or hip osteoarthritis in a Mediterranean country
TLDR
There was a significantly positive association between vitamin D levels and male gender and these findings indicate a large percentage of vitamin D deficient patients with knee or hip OA, which is unexpected considering the high annual insolation in northern Greece.
Knee effusion-synovitis volume measurement and effects of vitamin D supplementation in patients with knee osteoarthritis.
Low levels of vitamin D and worsening of knee osteoarthritis: results of two longitudinal studies.
TLDR
The findings indicate that vitamin D status is unrelated to the risk of joint space or cartilage loss in knee OA, and confidence limits in the analyses of vitamin D deficiency were narrow, suggesting that results were not based on insufficient power.
Diffuse Musculoskeletal Pain Is Not Associated With Low Vitamin D Levels or Improved by Treatment With Vitamin D
  • A. Warner, Sarah A Arnspiger
  • Medicine
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  • 2008
TLDR
Low vitamin D levels are not associated with diffuse musculoskeletal pain, and treatment with vitamin D does not reduce pain in patients with diffuse pain who have lowitamin D levels.
THU0197 The Effects of Vitamin D Levels on Pain Intensity, Muscle Strength and Functional Status of the Elderly Patients with Knee Osteoarthritis
TLDR
Vitamin D deficiency can be a contributor factor in pain, disability and muscle weakness in patients with knee osteoarthritis, and concomitant vitamin D deficiency should be considered in elderly patients with knees OA.
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