Vitamin D supplementation for the management of knee osteoarthritis: a systematic review of randomized controlled trials

@article{Hussain2017VitaminDS,
  title={Vitamin D supplementation for the management of knee osteoarthritis: a systematic review of randomized controlled trials},
  author={Salman Hussain and Ambrish Singh and Mohd. Akhtar and Abul Kalam Najmi},
  journal={Rheumatology International},
  year={2017},
  volume={37},
  pages={1489-1498}
}
Conflicting evidence exists concerning the supplementation of vitamin D in knee osteoarthritis condition. This systematic literature review was done to explore the effects of vitamin D supplementation in the management of knee osteoarthritis. Electronic literature search was done in databases like PubMed®, Embase®, and Cochrane CENTRAL from inception to 6th July 2016. The quality of included Randomized Controlled Trials (RCTs) was assessed using Cochrane risk of bias tool. We considered change… 

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Does Vitamin D Improve Osteoarthritis of the Knee: A Randomized Controlled Pilot Trial

There is a small but statistically significant clinical benefit to vitamin D treatment in patients with knee OA, although it is recommend a long‐term study to determine whether these changes are clinically important and whether they will be sustained with time.

Effect of Vitamin D Supplementation on Tibial Cartilage Volume and Knee Pain Among Patients With Symptomatic Knee Osteoarthritis: A Randomized Clinical Trial.

Among patients with symptomatic knee osteoarthritis and low serum 25-hydroxyvitamin D levels, vitamin D supplementation, compared with placebo, did not result in significant differences in change in MRI-measured tibial cartilage volume or WOMAC knee pain score over 2 years.

Effect of vitamin D supplementation on progression of knee pain and cartilage volume loss in patients with symptomatic osteoarthritis: a randomized controlled trial.

Vitamin D supplementation for 2 years at a dose sufficient to elevate 25-hydroxyvitamin D plasma levels to higher than 36 ng/mL, when compared with placebo, did not reduce knee pain or cartilage volume loss in patients with symptomatic knee OA.

Vitamin D status in patients with knee or hip osteoarthritis in a Mediterranean country

There was a significantly positive association between vitamin D levels and male gender and these findings indicate a large percentage of vitamin D deficient patients with knee or hip OA, which is unexpected considering the high annual insolation in northern Greece.

Low levels of vitamin D and worsening of knee osteoarthritis: results of two longitudinal studies.

The findings indicate that vitamin D status is unrelated to the risk of joint space or cartilage loss in knee OA, and confidence limits in the analyses of vitamin D deficiency were narrow, suggesting that results were not based on insufficient power.

Diffuse Musculoskeletal Pain Is Not Associated With Low Vitamin D Levels or Improved by Treatment With Vitamin D

  • A. WarnerSarah A Arnspiger
  • Medicine
    Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases
  • 2008
Low vitamin D levels are not associated with diffuse musculoskeletal pain, and treatment with vitamin D does not reduce pain in patients with diffuse pain who have lowitamin D levels.

THU0197 The Effects of Vitamin D Levels on Pain Intensity, Muscle Strength and Functional Status of the Elderly Patients with Knee Osteoarthritis

Vitamin D deficiency can be a contributor factor in pain, disability and muscle weakness in patients with knee osteoarthritis, and concomitant vitamin D deficiency should be considered in elderly patients with knees OA.