Vitamin D supplementation for prevention of mortality in adults.

@article{Bjelakovic2014VitaminDS,
  title={Vitamin D supplementation for prevention of mortality in adults.},
  author={Goran Bjelakovic and Lise Lotte Gluud and Dimitrinka Nikolova and Kate Whitfield and J{\o}rn Wetterslev and Rosa Giovanna Simonetti and Marija Dakovi{\'c} Bjelakovi{\'c} and Christian Gluud},
  journal={The Cochrane database of systematic reviews},
  year={2014},
  volume={1},
  pages={
          CD007470
        }
}
BACKGROUND Available evidence on the effects of vitamin D on mortality has been inconclusive. In a recent systematic review, we found evidence that vitamin D3 may decrease mortality in mostly elderly women. The present systematic review updates and reassesses the benefits and harms of vitamin D supplementation used in primary and secondary prophylaxis of mortality. OBJECTIVES To assess the beneficial and harmful effects of vitamin D supplementation for prevention of mortality in healthy… Expand
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TLDR
TSA of the 18 vitamin D trials shows that the futility area is reached after the 10th trial, allowing us to conclude that a possible intervention effect, if any, is lower than a 5% relative risk reduction. Expand
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TLDR
Vitamin D supplementation is ineffective as an agent for lowering BP and thus should not be used as an antihypertensive agent. Expand
Association between vitamin D supplementation and mortality: systematic review and meta-analysis
TLDR
Vitamin D supplementation alone was not associated with all cause mortality in adults compared with placebo or no treatment, and additional large clinical studies are needed to determine whether vitamin D3 supplementation is associated with lower allCause mortality. Expand
The D-Health Trial: A randomized trial of vitamin D for prevention of mortality and cancer.
TLDR
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Vitamin D for the treatment of chronic painful conditions in adults.
TLDR
There was no consistent pattern that vitamin D treatment was associated with greater efficacy than placebo in any chronic painful condition, and a large beneficial effect of vitamin D across different chronic painful conditions is unlikely. Expand
Vitamin D supplementation for chronic liver diseases in adults.
TLDR
To assess the beneficial and harmful effects of vitamin D supplementation in people with chronic liver diseases, 15 randomised clinical trials that compared vitamin D at any dose, duration, and route of administration versus placebo or no intervention were conducted. Expand
Vitamin D and outcomes in adult critically ill patients. A systematic review and meta‐analysis of randomized trials☆
TLDR
In critically ill patients, vitamin D administration might be associated with a reduction in mortality without significant adverse events, and a large multicenter randomized trial should conclusively confirm these findings. Expand
Vitamin D supplementation and lipid profile: what does the best available evidence show?
TLDR
For definitive answers to be given, large, well-designed RCTs need to be conducted that will take into account and adjust for dietary consumption as well as serum calcium and parathyroid hormone levels, both of which have been shown to be associated with the CV system. Expand
Vitamin D Status and Mortality: A Systematic Review of Observational Studies
TLDR
There is moderate evidence that vitamin D status is inversely associated with cancer mortality and death due to respiratory diseases, while for cardiovascular mortality, there is weak evidence of an association in observational studies, which is not supported by the data from intervention or Mendelian randomization studies. Expand
Vitamin D supplementation for chronic liver diseases in adults.
TLDR
This review update added 12 trials with 945 participants to assess the beneficial and harmful effects of vitamin D supplementation in adults with chronic liver diseases, and assessed all trials as at high risk of bias. Expand
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References

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TLDR
TSA of the 18 vitamin D trials shows that the futility area is reached after the 10th trial, allowing us to conclude that a possible intervention effect, if any, is lower than a 5% relative risk reduction. Expand
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