Vitamin D status is associated with muscle strength and quality of life in patients with COPD: a seasonal prospective observation study

@article{Carson2018VitaminDS,
  title={Vitamin D status is associated with muscle strength and quality of life in patients with COPD: a seasonal prospective observation study},
  author={E. L. Carson and L. Kirsty Pourshahidi and Sharon M. Madigan and Francina R. Baldrick and Martin Kelly and Eamon Laird and Martin Healy and J J Strain and Maria S. Mulhern},
  journal={International Journal of Chronic Obstructive Pulmonary Disease},
  year={2018},
  volume={13},
  pages={2613 - 2622}
}
Background Owing to hospitalization, reduced functional capacity and consequently, less sunlight exposure, suboptimal vitamin D status (25-hydroxyvitamin D [25(OH)D]⩽50 nmol/L) is prevalent among COPD patients. Objective This study aimed to investigate seasonal changes in vitamin D status and any associated changes in fat-free mass (FFM), muscle strength and quality of life (QoL) in COPD patients. Patients and methods COPD patients living in Northern Ireland (n=51) completed study visits at the… 

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References

SHOWING 1-10 OF 67 REFERENCES
Supplemental vitamin D and physical performance in COPD: a pilot randomized trial
TLDR
Among patients with severe COPD, 2000 IU of daily vitamin D for 6 weeks increased 25(OH)D to a level widely considered as normal, however, compared with placebo, short-term vitamin D supplementation had no discernible effect on a simple measure of physical performance.
Vitamin D status is associated with bone mineral density and functional exercise capacity in patients with chronic obstructive pulmonary disease
TLDR
The majority of COPD patients had vitamin D deficiency, and plasma 25(OH)D concentration was positively associated with bone density and exercise capacity, and intervention studies are necessary to determine whether vitamin D supplementation is of benefit in the prevention or treatment of osteoporosis and poor exercise capacity in patients with COPD.
Effects of daily vitamin D supplementation on respiratory muscle strength and physical performance in vitamin D-deficient COPD patients: a pilot trial
TLDR
Vitamin D supplementation did not affect (respiratory) muscle strength or physical performance in this pilot trial in vitamin D-deficient COPD patients, and primary outcomes did not differ between the groups after 6 months.
Vitamin D and skeletal muscle strength and endurance in COPD
TLDR
In contrast with healthy controls, muscle strength is not associated with vitamin D levels in COPD, which may represent vitamin D resistance.
Vitamin D status and physical function in older Finnish people: A one-year follow-up study.
Low vitamin D status is associated with reduced muscle mass and impaired physical performance in frail elderly people
TLDR
In this frail elderly population, 25(OH)D status is low and suggests a modest association with reduced ALM and impaired physical performance, which highlights the need for well-designed intervention trials to assess the impact of vitamin D supplementation in pre-frail and frail elderly people.
Hypovitaminosis D is associated with a reduction in upper and lower limb muscle strength and physical performance in post-menopausal women: a retrospective study
TLDR
The data showed that post-menopausal women with hypovitaminosis D had worse upper and lower limb muscle strength and physical performance than subjects with normal levels of 25(OH)D3.
Chronic Obstructive Pulmonary Disease Is Associated with Low Levels of Vitamin D
TLDR
COPD was associated with an increased risk of vitamin D deficiency, and important disease characteristics were significantly related to 25(OH)D levels.
Adiposity in relation to vitamin D status and parathyroid hormone levels: a population-based study in older men and women.
OBJECTIVE In small case-control studies, obesity was associated with worse vitamin D status. Our aim was to assess the association of adiposity (anthropometric measures as well as dual energy x-ray
Relationship between vitamin D and lung function, physical performance and balance on patients with stage I-III chronic obstructive pulmonary disease.
TLDR
Patients with COPD had worst physical functioning, poor balance and less muscle strength, and severe disturbed lung and peripheral muscle functions are more pronounced in COPD patients with vitamin D deficiency.
...
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