Vitamin D status in irritable bowel syndrome and the impact of supplementation on symptoms: what do we know and what do we need to know?

  title={Vitamin D status in irritable bowel syndrome and the impact of supplementation on symptoms: what do we know and what do we need to know?},
  author={Claire E. Williams and Elizabeth A. Williams and Bernard M. Corfe},
  journal={European Journal of Clinical Nutrition},
BackgroundLow vitamin D status is associated with risk of colorectal cancer and has been implicated in inflammatory bowel disease. Irritable bowel syndrome (IBS) is a chronic, relapsing, functional bowel disorder. A nascent literature suggests a role for vitamin D in IBS, but this has not been collated or critiqued. To date, seven studies have been published: four observational studies and three randomised controlled trials (RCTs). All observational studies reported that a substantial… 

Vitamin D supplementation in people with IBS has no effect on symptom severity and quality of life: results of a randomised controlled trial

There is no case for advocating use of vitamin D in the management of IBS symptoms and the prevalence of vitaminD insufficiency suggests routine screening and supplementation should be implemented in this population for general health reasons.

Vitamin D Supplementation and Mental Health in Inflammatory Bowel Diseases and Irritable Bowel Syndrome Patients: A Systematic Review

The conducted systematic review established the positive effect of vitamin D supplementation on the mental health of IBD and IBS patients, but this result requires further investigation, particularly in relation to other mental health outcomes.

Association of Serum Vitamin D Concentration With Clinical Symptoms and Quality of Life in Patients With Irritable Bowel Syndrome

A high prevalence of VDD was shown in patients with IBS and it was associated with a higher severity of clinical symptoms and lower QoL in IBS, and a direct significant association was seen between IBS-QoL and serum 25(OH)D3.

Association of the Vitamin D Level and Quality of School Life in Adolescents with Irritable Bowel Syndrome

There was a significant negative association of the 25-hydroxyvitamin D level with symptom severity and school absence and vitamin D supplementation could be considered as a choice of therapeutic method.

Effectiveness of vitamin D for irritable bowel syndrome

The findings of this systematic review may provide the existing evidence on the effectiveness and safety of VD for patients with IBS.

Role of vitamin D in pediatric irritable bowel syndrome

This article reviews the association between vitamin D and IBS in children and elaborates on the possible mechanism of action of vitamin D.

Irritable bowel syndrome: a review of the general aspects and the potential role of vitamin D

The understanding of the association of VD in IBS is indispensable for the development of new strategies that could improve the quality of life of the patient and the supplementation could help in the therapeutic approach for this condition.

Diet, Sun, Physical Activity and Vitamin D Status in Children with Inflammatory Bowel Disease

In the course of inflammatory bowel disease (IBD) malabsorption may lead to a vitamin D deficiency and calcium–phosphate misbalance. However, the reports on the vitamin D status in children with IBD

Effects of vitamin D3 supplementation on clinical symptoms, quality of life, serum serotonin (5-hydroxytryptamine), 5-hydroxy-indole acetic acid, and ratio of 5-HIAA/5-HT in patients with diarrhea-predominant irritable bowel syndrome: A randomized clinical trial

It is recommended that serum vitamin D be evaluated in the process of treatment of these patients to ameliorate symptoms and quality life of IBS-D patients with vitamin D deficiency and/or insufficiency.

The Relationship between Low Serum Vitamin D Levels and Altered Intestinal Barrier Function in Patients with IBS Diarrhoea Undergoing a Long-Term Low-FODMAP Diet: Novel Observations from a Clinical Trial

Data highlight the close relationship between VD and the intestinal barrier and support their involvement in IBS-D pathophysiology and the potentially positive role of LFD in the management of Ibs-D.



Vitamin D associates with improved quality of life in participants with irritable bowel syndrome: outcomes from a pilot trial

The IBS population exhibits significant levels of vitamin D insufficiency and would benefit from screening and possible supplementation, and the impact of IBS on quality of life may be reduced by vitamin D level.

Vitamin D3 as a novel treatment for irritable bowel syndrome: single case leads to critical analysis of patient-centred data

A case of a 41-year-old woman IBS sufferer who reported significant symptom improvements with high-dose vitamin D3 supplementation, and a systematic analysis of patient-centred, internet-based data surrounding this phenomenon.

Vitamin D Deficiency in Patients with Irritable Bowel Syndrome: Does it Exist?

This study shows that vitamin D deficiency is highly prevalent in patients with IBS and these results seem to have therapeutic implications, and vitamin D supplementation could play a therapeutic role in the control of IBS.

Vitamin D status in pediatric irritable bowel syndrome

Pediatric patients with IBS had significantly lower 25(OH)D concentration compared to controls despite having similar mean BMI values as controls, a much higher prevalence of vitamin D deficiency compared to IBD and other malabsorption syndromes.

Association Between Inflammatory Bowel Disease and Vitamin D Deficiency: A Systematic Review and Meta-analysis

IBD is significantly associated with having higher odds of vitamin D deficiency, and well-designed randomized controlled trials and longitudinal studies are needed to further explain the role ofitamin D in IBD pathogenesis and its therapy.

Effect of vitamin D on gastrointestinal symptoms and health‐related quality of life in irritable bowel syndrome patients: a randomized double‐blind clinical trial

Vitamin D could ameliorate the symptoms of patients suffering from IBS through its beneficial effects on psychological factors and inflammation.

Co-Administration of Soy Isoflavones and Vitamin D in Management of Irritable Bowel Disease

The results indicate that co-administration of soy isoflavones with vitamin D did not improve the IBS- SSS andIBS- QOL; however, it improved the Ibs-TS.

Vitamin D: An Evidence-Based Review

Little evidence guides clinicians on when to screen for vitamin D deficiency or effective treatment options, and many questions are raised regarding the role of maternal supplementation during lactation.

Diagnosis and management of IBS in adults.

Exercise, antibiotics, antispasmodics, peppermint oil, and probiotics appear to improve symptoms, and over-the-counter laxatives and antidiarrheals may improve stool frequency but not pain.

Meta-Analyses of Vitamin D Intake, 25-Hydroxyvitamin D Status, Vitamin D Receptor Polymorphisms, and Colorectal Cancer Risk

Evidence is supported of an inverse association between vitamin D intake, 25-hydroxyvitamin D status, and the BsmI VDR polymorphism and CRC risk and improving vitamin D status could be potentially beneficial against CRC incidence.