Vitamin D signalling pathways in cancer: potential for anticancer therapeutics

@article{Deeb2007VitaminDS,
  title={Vitamin D signalling pathways in cancer: potential for anticancer therapeutics},
  author={Kristin K. Deeb and Donald L. Trump and Candace Nicole Johnson},
  journal={Nature Reviews Cancer},
  year={2007},
  volume={7},
  pages={684-700}
}
Epidemiological studies indicate that vitamin D insufficiency could have an aetiological role in various human cancers. Preclinical research indicates that the active metabolite of vitamin D, 1α,25(OH)2D3, also known as calcitriol, or vitamin D analogues might have potential as anticancer agents because their administration has antiproliferative effects, can activate apoptotic pathways and inhibit angiogenesis. In addition, 1α,25(OH)2D3 potentiates the anticancer effects of many cytotoxic and… CONTINUE READING
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