Vitamin D sensitizes breast cancer cells to the action of H2O2: mitochondria as a convergence point in the death pathway.

@article{Weitsman2005VitaminDS,
  title={Vitamin D sensitizes breast cancer cells to the action of H2O2: mitochondria as a convergence point in the death pathway.},
  author={Gregory E. Weitsman and Ruth Koren and Efrat Zuck and Carmela Rotem and Uri A. Liberman and Amiram Ravid},
  journal={Free radical biology & medicine},
  year={2005},
  volume={39 2},
  pages={266-78}
}
Calcitriol, the hormonal form of vitamin D3, sensitizes breast cancer cells to reactive oxygen species (ROS)-dependent cytotoxicity induced by various anticancer modalities. This effect could be due to increased generation of ROS and/ or to increased sensitivity of the target cells to ROS. This work examined the effect of calcitriol on the damage inflicted on breast cancer cells by the direct action of ROS represented by H2O2. Treatment of MCF-7 cells with H2O2 resulted in activation of caspase… CONTINUE READING
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