Vitamin D rescues impaired Mycobacterium tuberculosis-mediated tumor necrosis factor release in macrophages of HIV-seropositive individuals through an enhanced Toll-like receptor signaling pathway in vitro.

@article{Anandaiah2013VitaminDR,
  title={Vitamin D rescues impaired Mycobacterium tuberculosis-mediated tumor necrosis factor release in macrophages of HIV-seropositive individuals through an enhanced Toll-like receptor signaling pathway in vitro.},
  author={Asha M Anandaiah and Santosh Kumar Sinha and Medhavi Bole and Sanjeev Kumar Sharma and Narendra Kumar and Kalpana Luthra and Xin Li and Xiuqin Zhou and Benjamin D. Nelson and Xinbing Han and Souvenir D. Tachado and Naimish R. Patel and Henry Koziel},
  journal={Infection and immunity},
  year={2013},
  volume={81 1},
  pages={
          2-10
        }
}
Mycobacterium tuberculosis disease represents an enormous global health problem, with exceptionally high morbidity and mortality in HIV-seropositive (HIV(+)) persons. Alveolar macrophages from HIV(+) persons demonstrate specific and targeted impairment of critical host cell responses, including impaired M. tuberculosis-mediated tumor necrosis factor (TNF) release and macrophage apoptosis. Vitamin D may promote anti-M. tuberculosis responses through upregulation of macrophage NO, NADPH oxidase… CONTINUE READING
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