Vitamin D related genes, CYP24A1 and CYP27B1, and colon cancer risk.

  title={Vitamin D related genes, CYP24A1 and CYP27B1, and colon cancer risk.},
  author={Linda M. Dong and Cornelia M Ulrich and Li Hsu and David Duggan and Debbie S. Benitez and Emily White and Martha L. Slattery and Federico M. Farin and Karen W. Makar and Christopher S Carlson and Bette Jane Caan and John D. Potter and Ulrike Peters},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  volume={18 9},
Genetic association studies investigating the role of vitamin D in colon cancer have primarily focused on the vitamin D receptor (VDR), with limited data available for other genes in the vitamin D pathway, including vitamin D activating enzyme 1-alpha hydroxylase (CYP27B1) and vitamin D deactivating enzyme 24-alpha hydroxylase (CYP24A1). We evaluated whether 12 tagging single nucleotide polymorphisms (SNP) in CYP24A1, identified by resequencing the gene in 32 Caucasian samples, and 1 SNP in… CONTINUE READING


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