Vitamin D reduces the inflammatory response by Porphyromonas gingivalis infection by modulating human β-defensin-3 in human gingival epithelium and periodontal ligament cells.

@article{Filippis2017VitaminDR,
  title={Vitamin D reduces the inflammatory response by Porphyromonas gingivalis infection by modulating human β-defensin-3 in human gingival epithelium and periodontal ligament cells.},
  author={Anna De Filippis and Margherita Fiorentino and Luigi Guida and Marco Annunziata and Livia Nastri and Antonietta Rizzo},
  journal={International immunopharmacology},
  year={2017},
  volume={47},
  pages={
          106-117
        }
}
Periodontitis is a multifactorial polymicrobial infection characterized by a destructive inflammatory process. Porphyromonas gingivalis, a Gram-negative black-pigmented anaerobe, is a major pathogen in the initiation and progression of periodontitis; it produces several virulence factors that stimulate human gingival epithelium (HGE) cells and human periodontal ligament (HPL) cells to produce various inflammatory mediators. A variety of substances, such as vitamin D, have growth-inhibitory… CONTINUE READING

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