Vitamin D receptor variants and uncontrolled asthma.

@article{Hutchinson2018VitaminDR,
  title={Vitamin D receptor variants and uncontrolled asthma.},
  author={Katrina Hutchinson and Conor P. Kerley and John L. Faul and Peter Greally and David Coghlan and M E Louw and Basil Elnazir and Yury A. Rochev},
  journal={European annals of allergy and clinical immunology},
  year={2018},
  volume={50 3},
  pages={
          108-116
        }
}
Summary Background. Asthma is a common childhood respiratory disease, affecting around 20% of Irish children. In other populations, vitamin D receptor (VDR) polymorphisms have been associated with asthma risk. We aimed to investigate the association between 2 VDR polymorphisms and uncontrolled paediatric asthma. Methods. 44 asthmatic children and 57 healthy volunteers were studied. The VDR TaqI gene variant in exon 9 (T/C) (rs731236) and ApaI (rs7975232) in intron 8 (C/T) were determined, using… 
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18 Citations
Background Citations
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Results Citations
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18 Citations

Citation Type

Citation Type

Genetic polymorphisms in vitamin D pathway influence 25(OH)D levels and are associated with atopy and asthma
TLDR
Genetic variants in the vitamin D pathway affect vitamin D serum levels and, thus, atopy and asthma, in teenagers from Northeast Brazil.
Association of vitamin D gene polymorphisms in children with asthma - A systematic review
Vitamin D Receptor Gene Polymorphism and susceptibility to Asthma: meta-analysis based on 17 case-control studies.
VDR Gene Polymorphisms and Allergic Diseases: Evidence from a Meta-analysis
TLDR
Combing the results of all relevant publications proved that VDR rs7975232 ApaI, rs1544410 BsmI and rs731236 TaqI gene polymorphisms may confer susceptibility to allergic diseases in certain populations.
Vitamin D plasma concentration and vitamin D receptor genetic variants confer risk of asthma: A comparison study of Taiwanese and Mongolian populations
Associations of VDR gene polymorphisms with risk of coal workers' pneumoconiosis in Chinese Han population.
TLDR
The results suggested that ApaI T allele and GT or TT genotype and lower 25(OH)2D levels were increased the risk of CWP in Chinese Han population.
Pediatric Pulmonology
TLDR
TaqI and BsmI were associated with risk of bronchial asthma development among Egyptian children and VDR‐single nucleotide polymorphisms (SNPs) detection has performed using polymerase chain reaction through restriction fragment length polymorphism technique.
Vitamin D Receptor Polymorphism and Myasthenia Gravis in Chinese Han Population
TLDR
In the Chinese Han population, rs731236 was found to be possibly associated with adult non-thymoma AChRAb negative MG patients, although this needs further confirmation.
Analysis of 25‐hydroxy cholecalciferol, immunoglobulin E, and vitamin D receptor single nucleotide polymorphisms (Apa1, Taq1, and Bsm1), among sample of Egyptian children with bronchial asthma: A case‐control study
The current study aimed to assess the serum levels of vitamin D and immunoglobulin E (IgE) among asthmatic Egyptian children and to find out the possible associations of vitamin D receptor (VDR)…
Exploration of Vitamin D Supplementation Adjuvant Therapy for Childhood Asthma and the Best Treatment Options
TLDR
The clinical outcome of vitamin D in the treatment of asthma is not as impressive as experimental studies, but comprehensively optimizing and applying these methods is beneficial to improve the therapeutic effect.
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References

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TLDR
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TLDR
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TLDR
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