Vitamin D receptor upregulation in alloreactive human T cells.

  title={Vitamin D receptor upregulation in alloreactive human T cells.},
  author={Richard W. Joseph and Ulas Darda Bayraktar and Tae Kon Kim and Lisa S. St. John and Uday Popat and Jahan S. Khalili and Jeffrey J. Molldrem and Eric D. Wieder and Krishna V Komanduri},
  journal={Human immunology},
  volume={73 7},
Vitamin D deficiency is adversely associated with diseases characterized by inflammation. The combination of the high incidence of vitamin D deficiency in patients undergoing allogeneic stem cell transplants (SCT) and the potential role of vitamin D deficiency in influencing graft-versus-host disease led us to further characterize the expression of VDR on alloreactive T cells. We hypothesized that vitamin D receptor expression may directly regulate alloreactive T cell responses. To overcome… CONTINUE READING
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