Vitamin D receptor start codon polymorphism (FokI) is related to bone mineral density in healthy adolescent boys

@article{Strandberg2003VitaminDR,
  title={Vitamin D receptor start codon polymorphism (FokI) is related to bone mineral density in healthy adolescent boys},
  author={Sara Strandberg and Peter Nordstr{\"o}m and Ronny Lorentzon and Mattias Lorentzon},
  journal={Journal of Bone and Mineral Metabolism},
  year={2003},
  volume={21},
  pages={109-113}
}
Abstract. Peak bone mass is considered a major determinant in the emergence of osteoporosis and is mainly genetically regulated. Several genes have been investigated, among them the vitamin D receptor (VDR) gene. A single-nucleotide polymorphism (defined by the endonuclease FokI) located in the start codon of the VDR creates the alleles F and f, resulting in different proteins. A number of previous studies have proved the F allele to be more advantageous as concerns bone mineral density (BMD… 
The vitamin D receptor fokl start codon polymorphism and bone mineral density in male hypogonadotrophic hypogonadism
TLDR
BMD levels were significantly lower in patients bearing heterozygous Ff genotype with IHH than homozygous FF ones, suggesting that fokl genotype might run down the BMD in cortical bone of femur, which needs to be proved in further studies.
The vitamin D receptor Fok1 polymorphism and bone mineral density in Chinese children.
Vitamin D and estrogen receptor-α genotype and indices of bone mass and bone turnover in Danish girls
TLDR
The findings suggest that the rate of bone resorption was influenced by ERα genotypes, even though these biochemical differences were not evident in bone mass indices.
The Relationship between Vitamin D Receptor Gene Polymorphisms and Bone Density, Osteocalcin Level and Growth in Adolescents
TLDR
There was a strong tendency for a higher BMD at the lumbar spine of TT and AA genotypes compared to tt and Aa genotypes, and VDR gene TaqI polymorphism may be associated with body weight and bone mass.
Vitamin D receptor gene polymorphism and bone mineral density in 0–6-year-old Han children
TLDR
The findings show that the Bb and ff genotypes of the VDR BsmI and FokI variants are significantly associated with a decreased BMD in Chinese Han children aged 0–6 years, while the V DR ApaI and TaqI polymorphisms are not significantly associatedWith it.
Vitamin D Receptor Polymorphisms and Bone Mass Accrual in Indian Girls
TLDR
In the current issue of the Journal, Sanwalka et al. have evaluated the association of Fok1 polymorphism with bone mass accrual in 102 Indian girls aged 8–16 y and found a significant increase in bone mineral content and BMD was seen across all genotypesFF, Ff and ff.
Vitamin D receptor gene start codon polymorphism (FokI) is associated with forearm bone mineral density and calcaneal ultrasound in Finnish adolescent boys but not in girls
TLDR
In adolescent boys, the Ff genotype was associated with higher forearm BMD and calcaneal ultrasound values, when adjusted for body and bone size, BsmI polymorphism, calcium intake, vitamin D status, smoking, and physical activity.
Association between vitamin D receptor gene polymorphisms (Fok1 and Bsm1) and osteoporosis: a systematic review
TLDR
Larger and more rigorous analytical studies with consideration of gene-gene and gene-environment interactions are needed to further dissect the mechanisms by which VDR polymorphisms influence osteoporosis.
Polymorphism in vitamin D receptor is associated with bone mineral density in patients with adolescent idiopathic scoliosis
TLDR
The results suggest that the VDR BsmI polymorphism is associated with LSBMD in girls with AIS, and no significant association was found between LS BMD or FNBMD and the V DR FokI or Cdx2 polymorphisms.
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