Vitamin D receptor mediates DNA repair and is UV-inducible in intact epidermis but not cultured keratinocytes

  title={Vitamin D receptor mediates DNA repair and is UV-inducible in intact epidermis but not cultured keratinocytes},
  author={Stephanie K. Demetriou and Katherine Ona-Vu and Arnaud E. Teichert and J. E. Cleaver and Daniel D Bikle and Dennis H. Oh},
  booktitle={The Journal of investigative dermatology},
While providing a powerful approach for studying epidermal biology, cultured keratinocytes may imperfectly model a three-dimensional epidermis in which cells are architecturally ordered. We report two important examples of the limitations of cultured keratinocytes in understanding vitamin D receptor (VDR) photobiology in murine skin. Recently, the vitamin D signaling pathway has been implicated in skin cancer prevention through its role in cellular responses to ultraviolet B radiation (UVB… CONTINUE READING

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