Vitamin D receptor gene polymorphisms and HLA DRB1*04 cosegregation in Saudi type 2 diabetes patients.

@article{AlDaghri2012VitaminDR,
  title={Vitamin D receptor gene polymorphisms and HLA DRB1*04 cosegregation in Saudi type 2 diabetes patients.},
  author={Nasser M Al-Daghri and Omar Salem Al-Attas and Majed Saleh Alokail and Khalid Mohammed Alkharfy and Hossam M. Draz and Cristina Agliardi and Abdul Khader Mohammed and Franca Rosa Guerini and Mario Clerici},
  journal={Journal of immunology},
  year={2012},
  volume={188 3},
  pages={1325-32}
}
The vitamin D receptor (VDR) gene has been involved in the modulation of susceptibility to inflammatory and autoimmune conditions, and could play a role in the pathogenesis of type 2 diabetes mellitus (T2DM). Susceptibility to T2DM was recently also suggested to associate with HLA alleles. We evaluated possible correlations between VDR polymorphisms, HLA alleles, and risk for development of T2DM by analyzing 627 individuals (368 T2DM patients and 259 healthy control subjects) part of a well… CONTINUE READING
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