Vitamin D receptor binding, chromatin states and association with multiple sclerosis

@inproceedings{Disanto2012VitaminDR,
  title={Vitamin D receptor binding, chromatin states and association with multiple sclerosis},
  author={Giulio Disanto and Geir Kjetil Ferkingstad Sandve and Antonio J. Berlanga-Taylor and Giammario Ragnedda and Julia M. Morahan and Corey T. Watson and Gavin Giovannoni and George Cornell Ebers and Sreeram V Ramagopalan},
  booktitle={Human molecular genetics},
  year={2012}
}
Both genetic and environmental factors contribute to the aetiology of multiple sclerosis (MS). More than 50 genomic regions have been associated with MS susceptibility and vitamin D status also influences the risk of this complex disease. However, how these factors interact in disease causation is unclear. We aimed to investigate the relationship between vitamin D receptor (VDR) binding in lymphoblastoid cell lines (LCLs), chromatin states in LCLs and MS-associated genomic regions. Using the… CONTINUE READING