Vitamin D receptor and retinoid X receptor α status and vitamin D insufficiency in models of murine colitis.

@article{Knackstedt2013VitaminDR,
  title={Vitamin D receptor and retinoid X receptor α status and vitamin D insufficiency in models of murine colitis.},
  author={Rebecca Knackstedt and Vondina R. Moseley and Shaoli Sun and Michael J. Wargovich},
  journal={Cancer prevention research},
  year={2013},
  volume={6 6},
  pages={585-93}
}
The anti-inflammatory actions of vitamin D have long been recognized and its importance in modulating colon cancer and colitis development is becoming apparent. The vitamin D receptor (VDR) is downregulated in human ulcerative colitis and colitis-associated cancer (CAC); however, its status in murine models of colitis has yet to be explored. Snail and Snail2, zinc-finger transcription factors regulated by inflammatory pathways and able to transcriptionally silence VDR, are upregulated in human… CONTINUE READING