Vitamin D receptor: no evidence for allele-specific mRNA stability in cells which are heterozygous for the Taq I restriction enzyme polymorphism.

@article{Verbeek1997VitaminDR,
  title={Vitamin D receptor: no evidence for allele-specific mRNA stability in cells which are heterozygous for the Taq I restriction enzyme polymorphism.},
  author={W. H. J. Verbeek and Adrian. F. Gombart and Masaaki Shiohara and Muriel Campbell and H Phillip Koeffler},
  journal={Biochemical and biophysical research communications},
  year={1997},
  volume={238 1},
  pages={77-80}
}
Allelic variations of the vitamin D receptor (VDR) gene have been associated with the risk of developing prostate cancer in men and osteoporosis in postmenopausal women. Three RFLPs (TaqI, ApaI, BsmI) define two common haplotypes: BAt and baT. None of these polymorphisms change the translated protein. Since sequence variations in the 3' UTR of VDR have been linked to the different haplotypes, investigators have proposed that the stability of VDR mRNA is influenced by allelic variations… CONTINUE READING