Vitamin D receptor: mechanisms for vitamin D resistance in renal failure.

@article{Dusso2003VitaminDR,
  title={Vitamin D receptor: mechanisms for vitamin D resistance in renal failure.},
  author={Adriana S. Dusso},
  journal={Kidney international. Supplement},
  year={2003},
  volume={85},
  pages={S6-9}
}
1,25-dihydroxyvitamin D [1,25(OH)2D3], the hormonal form of vitamin D, controls serum levels of parathyroid hormone (PTH) and parathyroid hyperplasia. Both 1,25(OH)2D3 actions involve regulation of gene transcription by the 1,25(OH)2D3/vitamin D receptor (VDR) complex. In advanced renal failure, in addition to low serum 1,25(OH)2D3 and reduced parathyroid vitamin D receptor content, several mechanisms downstream from 1,25(OH)2D3/VDR complex formation contribute to the impairment of 1,25(OH)2D3… CONTINUE READING

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