Vitamin D protects human endothelial cells from H₂O₂ oxidant injury through the Mek/Erk-Sirt1 axis activation.

@article{Polidoro2013VitaminDP,
  title={Vitamin D protects human endothelial cells from H₂O₂ oxidant injury through the Mek/Erk-Sirt1 axis activation.},
  author={Lorella Polidoro and Giuliana Properzi and Francesco Marampon and Giovanni Luca Gravina and Claudio Festuccia and Erica Di Cesare and Luca Scarsella and Carmela Ciccarelli and Bianca Maria Zani and Cinzia Ferri},
  journal={Journal of cardiovascular translational research},
  year={2013},
  volume={6 2},
  pages={221-31}
}
Endothelium homeostasis alterations govern the pathogenesis of cardiovascular diseases. Several studies show that vitamins anti-oxidant proprieties rescue the endothelial functions adversely affected by oxidative stress in several diseases. We investigated the vitamin D anti-oxidant potential in human endothelial cells exposed to H2O2 oxidative stress. Vitamin D protected endothelial cells against H2O2 oxidative stress counteracting the superoxide anion generation, the apoptosis and blocking… CONTINUE READING
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