Vitamin D metabolites change the phenotype of monoblastic U937 cells.

  title={Vitamin D metabolites change the phenotype of monoblastic U937 cells.},
  author={R C Dodd and Myron S. Cohen and Simon L. Newman and Terence K. Gray},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={80 24},
U937 is a human-derived lymphoma cell line that has monoblastic properties and high-affinity receptors for 1 alpha,-dihydroxyvitamin D3. Incubation of these cells with the vitamin D metabolite at 10 nM for 5 days produced marked stimulation in adherence and ingestion of Staphylococcus aureus (645% of control) and of C3b receptor (CR1) expression (292% of control) and a slight increase in hexose monophosphate shunt activity without changing cell growth rates or Fc fragment receptor expression… CONTINUE READING
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